819 results
- Is the apomorphine micro-emulsion effective and safe?- Does iontophoresis improve the clinical effect and safety of the micro-emulsion?- Does surfactant improve the effectiveness of the micro-emulsion with iontophoresis without changing the safety
The primary objective of this study is to identify the neural correlates of language functions and, in particular, abnormal pragmatic communication in autistic spectrum disorders.
This study aims to show increased microglia activation in brain parts involved in PD pathology, comparing PD patients with age-matched healthy control subjects. To see whether microglia activation changes early in the course of Parkinson*s disease (…
Investigate whether in Parkinson's Disease a disturbed body schema (awareness of one' own body posture) leads to disturbed motor planning, and whether brain regions involved in this process show an impaired activity.
In this study we would like to investigate whether cerebral perfusie and cerebral metabolism can be influenced with pharmacological agents in patients with MS and in healthy control persons. Cerebral perfusion and cerebral metabolism wil be measured…
The aim of this study is to gain understanding of the functioning of spinal reflexes in patients with MD, using a new method involving EMG, EEG and the wrist manipulator.
The purpose of the present study is to try to classify autistic children into distinct subgroups, by clinical morphological examination. We mainly want to answer the following questions: 1) Is there an increased prevalence of minor anomalies in…
The aim of the study is to describe the incidence and characteristics of CRPS in the Dutch population. Also will be investigated which factor are associated with the ocurrence of the disease.
In our longitudinal study we would like to investigate whether measures of neuronal damage, glial damage and oxidative stress are correlated with the speed of progression of disability. We would also like to investigate whether these variables…
1. The development of a standardized screeningsinstrument to evaluate the language comprehension of severly handicapped children with movement disorders and who cannot speak, as a result of white matter damage.2.To evaluate the difference between…
To answer the question if structural changes of the brain and impairments of cognitive functioning in type 1 diabetes are related to the presence of microvascular disease we will· Compare brain structure (brain volume, white matter lesions) and…
To determine to what extent dynamic spasticity can be recognized and quantified in the gait pattern of children with spastic CP and to develop a meaningful and (clinically) applicable measure of dynamic spasticity
Aim of this study is to compare the effects of mannitol and HS in equimolar concentrations on cerebral blood flow, cerebral oxygenation, metabolism and inflammation in patients with severe TBI.
We hypothesize that bilateral globus pallidus internus (GPi) DBS produces greater functional improvement in PD than bilateral STN DBS because of a lower rate of complications.
The objective of this study is twofold.One aim of the study is to investigate the effects of tDCS (anodal, cathodal and sham) on balance correcting responses and simple reaction times in lower extremity muscles. We will determine whether the effects…
1. The objective of this study is to aquire knowledge about the development of reactive hyperaemia and inflammatory responses of the skin after shear- force and pressure loading. We want to investigate if patients with diabetes type 2 will develop…
Main objectiveTo investigate whether dopamine affects the ability to initiate the correct step in response to a sudden change (improbable picture in a predictable context) in PD with and without FOG. Secondary objectiveTo investigate whether…
1. Characterize the interplay between host factors and bacterial factors and the specific activation of inflammatory pathways.2. Evaluate the expression of identified risk genes after activation of inflammatory pathways in host immune mediating…
The main aims of our study are 1) to make a clinical inventory of MD cases, 2) to identify (modifier) disease genes underlying MD and 3) to link the clinical data with the genetic data in a data-base.
The main goal of the VUmc part of the study is to acquire sets of data related to Neurological and Neuromuscular Diseases; in order to build a paediatric digital repository and to develop biophysical modelling and probabilistic modelling.