819 results
Primary objectiveTo assess the safety and tolerability after single and multiple intravenous administrations of PPSGG in patients suffering from anti-MAG neuropathy.Secondary objectives- To evaluate the PK of PPSGG after single and multiple…
The study objective is primarily to measure the effect of an online cognitive training in patients with mild cognitive complaints in PD. An online training, specifically altered for PD patients (BrainGymmer) will be compared with an active online…
To improve prediction of neurological and functional outcome at school age in infants at high risk of cerebral palsy.
The primary objective of this study is to determine the relative contributions of PD diagnosis and dopaminergic medication use to the changes in microbiota composition observed in PD patients. Secondary objectives are to determine the relative…
BEWARE 2.0: body awareness training for wearing-off related distress in Parkinson's disease patients
Do patients that receive the BEWARE training have a higher score on the Chronic Illness Acceptance Questionnaire at the end of treatment (and at 3 month follow-up) compared to the treatment as usual (physical therapy only)?
The main objectives are to understand how clinical markers and biomarkers previously identified in younger and older AD cohorts apply to the extreme elderly (90+ years old) and to identify novel biomarkers linked with resilience to developing…
Our objective is to find predictive biomarkers for disease progression in RVCL-S, a monogenetic small vessel disease, and to dissect disease mechanism to identify new treatment targets to improve health for RVCL-S patients, which may also serve as…
The primary objective is to determine if there is a difference in autonomic function between patients with Alzheimer*s disease (MCI and AD) and a matched control group. The secondary objectives will be explorative and aimed to investigate…
To investigate whether treatment of dystonia causing varus tilt of the hindfoot in Parkinson*s disease is more effective when botulinum toxin type A is combined with complementary functional gait training compared to botulinum toxin type A treatment…
The primary objective is to determine and compare the microvascular status between middle-aged women with and without migraine. Secondary objectives include a determination of the agreement and reproducibility of two devices which measure the blood…
To investigate the effect of explantation of silicone breast implants on neuroimaging of the brain (fMRI) in ASIA syndrome patients to gain more insight in the neurophysiological basis and nociceptive system of ASIA syndrome due to SIIS and the…
Main objectives are:1. To explore differences in cerebral perfusion and flow pulsatility between CoA patients and controls.2. To quantify ischemic white matter lesions and cerebral microbleeds in CoA patients with comparison to controls.Secondary…
Our research aims to establish informative tools in the laboratory for studying the molecular and cellular pathways that are altered in SETBP1 disorder.
The aim of this study is to gauge the feasibility and potential order-of-magnitude the ReHab-TOAT concept may have on improving arm-hand skill performance in both subacute and chronic stroke patients. These data will be used to a) optimize the…
The primary objective of this study is to evaluate differences in motor evoked potential (MEP) and TMS evoked potential (TEP) to paired pulse TMS between epilepsy patients and healthy controls. Secondary objectives are 1) To evaluate differences in…
To demonstrate that ofatumumab is superior to teriflunomide in reducing the frequency of confirmed relapses as evaluated by the annualized relapse rate (ARR) in patients with relapsing MS
Primary objective of this study: To establish glycocalyx properties of temporal lobe epilepsy (TLE) patients. Secondary objectives of this study:- To establish differences in glycocalyx properties of glycocalyx between TLE patients and controls.- To…
The key objective of the study is to assess the validity of a quantitative uniform examination technique for estimating physiological properties in MND patients, to better examine the neuromuscular properties from which defective motor behavior…
This pilot study aims to explore whether and why the cardiorespiratory fitness is compromised in newly diagnosed patients with early Relapsing Remitting Multiple Sclerosis (RRMS) with no or minimal clinical symptoms (i.e. Expanded Disability Status…
1) To study the effects of antibody removal by immunoadsorption on the immune phenotype over time in patients with B-cell related autoimmune diseases such as MG, AAV, anti-GBM disease, cryoglobulinemic vasculitis and other refractory antibody-…