819 results
Primary Objective: To investigate whether a quantitative MRI protocol can detect the difference between atypical parkinsonism and patients with Parkinson*s disease, in an early phase of the diseases when the clinical diagnosis for either is not yet…
The primary objective of this study is to study signs of small fiber neuropathy in PGAS patients compared to healthy controls.
This study has been transitioned to CTIS with ID 2023-505483-11-00 check the CTIS register for the current data. To investigate if early transition to oral treatment after two weeks or longer of IV antibiotic therapy is non-inferior to standard six…
Offloading the peak plantar pressure in Diabetic patients with loss of protective sensation by using the self-adjusting insoles and individually optimized rocker profiles. The secondary objective is to evaluate the effect of the self-adjusting…
The primary objectives of this study are to assess the safety and estimate the radiation dose of the radioligand [18F]FB610, and to assess the optimal kinetic model for quantification of the tracer uptake. Secondary objectives are to determine…
We hypothesize that using the Evotouch/7stascope, ultrasound guided TFEI procedures are non-inferior to the golden standard with fluoroscopy, which means correct placement of the needle within the neuroforamen without intravascular positioning.
The primary objective of the second part of the study, which is the focus of this application, is to perform a comparative analysis of the cognitive profile and MRI outcomes of DMD/BMD patients.
The primary objective is to evaluate longitudinal developmental changes in brain structure in patients aged 6-18 years with SCD. The secondary objective is to analyze the longitudinal relations between biomarkers, demographic characteristics, brain…
Part A:The primary objective is to test the efficacy of the Myosuit, a soft exosuit, for increasing daily life gait performance in the home and community setting in people with iSCI. Secondary, the efficacy of the Myosuit program on gait capacity…
Test whether a mindfulness-based cognitive therapy intervention (MBCT) improves psychological distress, clinical symptoms, slows neurodegeneration, and/or enhances neuroplasticity in PD.
The primary objective of the current study is to assess the feasibility of ROBERT® -SAS training in clinical setting, in acute stroke patients, including patient and therapist perspectives
The primary objective of this clinical feasibility study in people with PD is to evaluate the feasibility and potential efficacy of home-based gamified AR gait-and-balance exercises with Cue X. Secondary objectives of this study are to validate the…
Safety: To provide confirmatory evidence that use of the LIFT System, inclusive of all components and accessories, is safe.Effectiveness: To provide confirmatory evidence that use of the LIFT System provides an effective treatment for the…
To make an evidence-based recommendation on which method has the best efficacy (PROM), patient treatment experience (PREM) and safety profile (complications).
To 1) clinically validate the novel PET-tracer [18F]AV1451 for tau pathology as a diagnostic and prognostic marker in tauopathies, 2) to examine the (change in) (regional) binding of [18F]AV1451 across tauopathies, and the relationships between (…
The primary objective of the present study is to explore the safety and feasibility of electrical stimulation in patients with diverse kinds of nerve lesions. The secondary objective is to make a reasonable estimation of clinical effect size, which…
Primary Objective: To study alterations in metabolic balance in ALS patients and their impact on disease progression and survival.Secondary Objective(s): 1. To evaluate and compare the metabolic balance in patients with ALS and neurological control…
The primary objective of the study as a whole (part A-C) is to assess the PK and safety of buccal apomorphine relative to registered apomorphine formulations (subcutaneous, sublingual). Secondary objectives are the characterization of the PK-AE…
This study has been transitioned to CTIS with ID 2024-517127-40-00 check the CTIS register for the current data. To study the effects of continuous use of ethinylestradiol/levonorgestrel (30/150 µg/day) compared to vitamin E (400 IU/day) in the…
The overall aim of this study is to investigate clinical risk factors and MR markers that affect disease progression to gain more insight in targets for prevention and therapy and to better inform patients on prognosis.