819 results
The purpose of this post-approval protocol amendment is to extend the follow-up of subjects who were originally enrolled in theRCT, EUBARD-CP_001 protocol. This study extension will examine the long-term survivorship of the Barricaid® ACD when…
The primary objective of this trial is to assess the efficacy of immediate CAS among patients with acute ischemic stroke treated with EVT and a severe ipsilateral proximal carotid artery stenosis (>50%) or occlusion and compare this with the…
Research question(s). There are two specific questions to be addressed:1) Is percutaneous transforaminal endoscopic discectomy (PTED) no worse in effectiveness than conventional unilateral open microdiscectomy for patients with symptomatic…
1) To validate structural and functional changes (previous found in ALS patients) in other motor neuron disease and ALS mimicking syndromes and healthy control subjects 2) Explore brain alterations of asymptomatic family members in case of ALS, to…
Our main objective is to conduct a pilot study testing the applicability and face/external validity of the battery in a young-onset PD cohort, alongside age-matched healthy controls. We aim to gain deeper insights into the complex interrelationships…
This proof-of-principle evaluation aims to investigate whether a home-based balance training using an exergame (HEROES), following a single session of perturbation-based training improves reactive step quality in people with chronic stroke.
The aim of this research project is to study a large a group of patients with tonic dystonia longitudinally, to accurately describe the phenotype, to investigate the potential underlying mechanisms and to identify possible causes and risk factors.
The BeyeOMARKER study*s primary aim is to (1) evaluate the real-world predictive value of blood- and eye-based biomarkers for detection of AD-related clinical progression and biological changes in eye clinics. Secondly, we aim (2) to assess the…
The objective of this pilot study is to evaluate the effects of separate individualization of the AFO stiffness towards plantar- and dorsiflexion in a spring-hinged NEURO SWING AFO compared to a spring-like AFO without hinge (3 types) having the…
The aim of this longitudinal study is to find new biological, clinical and/or electrophysiological biomarkers in order to define and differentiate individual diagnoses of NT1 and the NBL, and to find improved treatment targets and strategies.
This study has been transitioned to CTIS with ID 2023-509345-12-00 check the CTIS register for the current data. The purpose of the study is to provide efficacy, safety and tolerability data for remibrutinib to support regulatory approval worldwide…
We propose cortical electrical stimulation therapy of a conceptually novel type. We systematically determine individual settings, stimulation site and seizure detection algorithm in a predictive model. In REC2Stim (Rational Extra-eloquent Closed-…
The main objective of this study is to investigate the acute beneficial effect of moderate inten-sive exercise (defined as walking) on neurocognitive functioning in healthy children and adults with mild CP, GMFCS I and II and if this effect is…
The primary aim of this study is to assess the effect of a personalized training intervention on CRF during primary rehabilitation. Secondary aims of this study are to determine the effect of this intervention on gait capacity, pulmonary function,…
This study will allow the assessment of the ability of CFZ533 to replace calcineurin inhibitors (CNIs) in terms of anti-rejection efficacy, while providing potentially better renal function with an expected similar safety and tolerability profile.…
Primary objective: To assess the effect-of initial DXM therapy versus primary surgery on functional outcome (as expressed by the mRS) and costs in patients with a newly diagnosed CSDH respectively after 3 and 12 months.Secondary objectives are:…
The overall aim of this study is to assess WML and associated existing and novel SVD imaging markers to dissect the pathophysiological mechanisms underlying WML in young to middle aged women at risk for future cardiovascular disease. We aim to…
The aim of this study is to assess the safety and the potential efficacy of personalized Local Field Potential (LFP)-based adaptive Deep Brain Stimulation (aDBS), using the implantable pulse generator (IPG), «AlphaDBS» System, in Parkinson*s Disease…
Primary objective:To evaluate the efficacy of ION-682884, based on the change from Baseline in serum Transthyretin (TTR) concentration, modified Neuropathy Impairment Score +7 (mNIS+7), and Norfolk Quality of Life Questionnaire-Diabetic Neuropathy (…
This project focuses on the characterization of the immune response following a traumatic SCI. As individual components of the immune response work in close collaboration and have a strong influence on each other, it is important to obtain a very…