819 results
We aim to determine onset of SCA6 disease more accurate then with the clinical scores and questionnaires that are currently used. We will study motor performance, motor learning behavior, PPI and MRI scans in pre-symptomatic SCA6 patients and…
Key hypothesis of the investigation is that Parkinson*s disease is characterized by deficient entrainment of slow brain oscillations. Our previous work already provides preliminary support for this hypothesis. In order to evaluate to what extent…
Primary: Does immunomodulation brought about by interferon beta-1a (Rebif) enhance or prolong functional reorganization in subjects with RRMS?Secondary: Does interferon beta-1a (Rebif) also affects functional connectivity as measured by resting-…
The aim of this study is to investigate the possible consequences of generic-generic substitution of gabapentin, a frequently used anti-epileptic drug.
Primary objective: To set up a repository of genetic material from a large group of well phenotyped people with epilepsy patients to allow the case control association studies, to analyze and detect genetic risk factors for epilepsy. Secondary…
1. To compare the induction of a procoagulant state between patients undergoing PVI using the PVAC catheter, the cryoballoon catheter or the cooled tip catheter.2. To compare the incidence of CE on diffusion weighted MRI between the three groups of…
Primary: - What are the effects of gait training with the gait rehabilitation device LOPES on the quality and ability of walking in chronic stroke patients with a stiff-knee gait?- What are the effects of two different training modes in the gait…
The purpose of this research line is to assess whether measures acquired with advanced MR neuroimaging can be used as neuropathological markers for the early diagnosis of dementia and differentiation between AD and FTD. For each project, the…
To evaluate the long term changes in quadriceps muscle function in patients with PPS in comparison with control subjects. To correlate changes in muscle strength, functioning and symptoms with changes in motor unit size. To evaluate long-term…
The aim of the study is to answer the following questions:On which measures do patients with aphasia seem to differ from controls matched on age and country of origin, in the analysis of the spontaneous speech according to the guidelines of the ASTA…
1) Identify and further explore the structural and functional brain alterations in ALS patients, PSMA patients annd PLS patients in comparison to healthy controls and ALS mimic sydromes, both cross-sectional and longitudinal; 2) Explore anatomical…
Primary Objective: To demonstrate the cost-effectiveness of treatment with a ketogenic diet compared to usual care in children with drug-resistant epilepsy who are not eligible for epilepsy surgery. Usual care is defined as: the child continuous to…
The main objective of the study is to achieve knowlegde on change in seizure semiology with age in children with partial epilepsy and to improve the understanding in the cause and consequence of this change, in relation to changing functional…
(1) Evaluate whether stroke patients differ from healthy controls on the experience and the course of subjective cognitive complaints during the first two years after stroke;(2) Evaluate potential predictors for cognitive complaints during the first…
The primary objective in this study is to compare the effectiveness of lateral C1-2 pulsed radiofrequency application (LPRF) in comparison with conventional C3-5 facet denervation (MBRF) in patients with clinically defined cervicogenic headache.
- To detect carotid and aortic plaque morphology and long term plaque behaviour in patients with cerebral and cardiac end-organ damage (NSTEMI / STEMI and TIA / CVA) with 1.5T MRI-derived virtual histology and relation to biomarkers.- To correlate…
The main objective of this study is to examine the effect of different kinds of augmented feedback on learning an arm motor task.
Primary Objective: To relate the ability to react in time to postural perturbations to set-shifting performance in Parkinson*s disease patients.Secondary Objective: To investigate the difference in set-shifting stepping responses between PD and…
To clarify the aetiology of CTS and prognostic factors for the development of CTS.
Primary objectiveTo determine whether a second IVIg dose in GBS patients with a poor prognosis improves functional outcome after 4 weeks.Secondary objectives To investigate whether: - a second IVIg dose in GBS patients with a poor prognosis improves…