143 results
1) Can changes in functional brain networks in patients with and without hallucinations from several psychiatric, neurological, and perceptual disorders be detected? And if so, what is the pattern of change in these diseases?2) Are specific changes…
The objective of this pilot study is to provide further insights about the neural correlates of teeth clenching (during awake state) and tmd pain in bruxers and non-bruxers or more specific:The primary objective of the study is to provide further…
Currently, all rotigotine transdermal patches are manufactured at 1 manufacturing site. A second site has been built to manufacture the same patches. Before these patches may be used, it needs to be investigated if they are exactly the same as those…
Deulevodopa in combination with carbidopa is a combination in development for the treatment of patients with Parkinson*s disease.The effects of deulevodopa taken with carbidopa have not yet been tested in humans, and there are no available clinical…
The primary objective is to study how brain and muscles work together during the onset of walking, during turns and during prolonged walking and whether there are differences between healthy individuals and PD patients with and without FOG.…
The study objective is primarily to measure the effect of an online cognitive training in patients with mild cognitive complaints in PD. An online training, specifically altered for PD patients (BrainGymmer) will be compared with an active online…
The primary objective of this study is to determine the relative contributions of PD diagnosis and dopaminergic medication use to the changes in microbiota composition observed in PD patients. Secondary objectives are to determine the relative…
BEWARE 2.0: body awareness training for wearing-off related distress in Parkinson's disease patients
Do patients that receive the BEWARE training have a higher score on the Chronic Illness Acceptance Questionnaire at the end of treatment (and at 3 month follow-up) compared to the treatment as usual (physical therapy only)?
To investigate whether treatment of dystonia causing varus tilt of the hindfoot in Parkinson*s disease is more effective when botulinum toxin type A is combined with complementary functional gait training compared to botulinum toxin type A treatment…
Primary objective: To investigate the prevalence of bruxism and TMD in PD patients through objective measurements and to identify factors associated with a higher risk of developing these symptoms.Secondary objectives: - To investigate the salivary…
Primary Objectives* To investigate the intra-variability (day-to-day) of glucocerebrosidase pathway biomarkers in HV, PD-GBA+ and PD-GBA-Secondary Objectives* To investigate the intra-variability (within-day) of glucocerebrosidase pathway biomarkers…
The primary objectives of this study are to assess the safety and estimate the radiation dose of the radioligand [18F]FB610, and to assess the optimal kinetic model for quantification of the tracer uptake. Secondary objectives are to determine…
Test whether a mindfulness-based cognitive therapy intervention (MBCT) improves psychological distress, clinical symptoms, slows neurodegeneration, and/or enhances neuroplasticity in PD.
The primary objective of this clinical feasibility study in people with PD is to evaluate the feasibility and potential efficacy of home-based gamified AR gait-and-balance exercises with Cue X. Secondary objectives of this study are to validate the…
The primary objective of the study as a whole (part A-C) is to assess the PK and safety of buccal apomorphine relative to registered apomorphine formulations (subcutaneous, sublingual). Secondary objectives are the characterization of the PK-AE…
Main objective:To demonstrate superior efficacy with evobrutinib compared to Teriflunomide in terms of Annualized Relapse Rate (ARR) Secondary objectives:a.To demonstrate the efficacy of evobrutinib relative to that of Teriflunomide on disability…
In this project we aim to evaluate whether a non-pharmacological and tailored intervention targeting anxiety- and stress-related FOG in people with PD is effective to reduce the impact of anxiety and stress on FOG. Specifically, we aim to study: (1…
The primary objective is to determine the feasibility of a remote intervention study to promote physical activity in people with iRBD. The secondary objectives are to determine the longitudinal effect of an exercise intervention in people with iRBD…
Objective 1: To improve the understanding of the dynamic phenotypic spectrum and the disease mechanisms of HD by:a. collecting natural history data covering the cognitive, behavioral and motor domains permitting estimates of rates of progression in…
The primary objective is to determine the time until maximum effect is reached of inhaled levodopa on motor function of Parkinson's disease patients during an off period. The secondary objectives are to determine the clinical improvement of…