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Non-surgical treatment of Carpal Tunnel Syndrome by means of Mechanical Traction: a Randomized Clinical Trial. The MT-CTS project

The aim of this study is to investigate the effectiveness of the Phystrac in people with Carpal Tunnel Syndrome.The primary research question is:- Is there evidence that Phystrac might be an additional non-invasive option of treating CTS patients…

Effects of a structured progressive task-oriented circuit training program to enhance walking competency after stroke

The primary aim of this study is to evaluate the effects of a structured, progressive task-oriented fitness training program applied in a group of 8 to 10 patients on perceived outcome of mobility after stroke when compared to individually-tailored…

Wii-balance therapy for patients after stroke

To determine whether Wii balance therapy is more effective than the conventional balance therapy for the standing and walking balance of patients with a stroke.

Cognitive sequelae of Prophylactic Cranial Irradiation in non-small cell lung cancer patients

The goal of PCI is to increase the neurological disease-free survival, without significant side effects, and hence to improve HRQOL. This sub-study aims to investigate this expected advantage of PCI in NSCLC in maintaining function and increasing…

A randomized, open-label, four-way cross-over, single dose study to compare the pharmacokinetics of monomethyl fumarate and other metabolites after administration of dimethyl fumarate as a delayed- and slow-release formulation of FP187 and Tecfidera® in healthy volunteers.

Primary ObjectiveThe primary objective is to investigate the PK of the MMF * the main metabolite of DMF * following administration of a delayed-and slow-release tablet formulation (FP187-GC) and the marketed enteric-coated delayed release…

A randomized, double-blind, double-dummy, parallel-group study comparing the efficacy and safety of ofatumumab versus teriflunomide in patients with relapsing multiple sclerosis

To demonstrate that ofatumumab is superior to teriflunomide in reducing the frequency of confirmed relapses as evaluated by the annualized relapse rate (ARR) in patients with relapsing MS

An open-label, single arm, multi-centre, phase II study investigating safety, tolerability, efficacy, pharmacodynamics and pharmacokinetics of imlifidase (IdeS) in patients with Guillain-Barré Syndrome (GBS), in comparison with matched control patients

The objectives of this study are to:• Assess safety and tolerability of imlifidase in combination with standard IVIg treatment in GBS subjects• Evaluate pharmacokinetics of imlifidase• Evaluate pharmacodynamics profile of imlifidase• Evaluate…

Improving cognitive performance in MS by transcranial alternating current brain stimulation (tACS): a pilot study

Here we will test the hypothesis that tACS (theta-tACS at 6 Hz) will enhance brain synchrony in MS patients, thereby improving their cognitive functioning. We further want to achieve the increase in fronto-temporal brain synchronization measured by…

A randomized, double-blind, double-dummy, parallel-group study, comparing the efficacy and safety of remibrutinib versus teriflunomide in participants with relapsing multiple sclerosis, followed by extended treatment with open-label remibrutinib.

This study has been transitioned to CTIS with ID 2023-509345-12-00 check the CTIS register for the current data. The purpose of the study is to provide efficacy, safety and tolerability data for remibrutinib to support regulatory approval worldwide…

Errorless learning and Goal Management Training in Parkinson*s disease

The primary objective is to examine the efficacy of a combined Errorless Learning and Goal Management Training intervention for treatment of cognitive complaints in Parkinson's disease, focusing on a more effective performance on IADL tasks…

A Phase 2/3, Multicenter, Double-Blind, Randomized Study to Determine the Efficacy and Safety of Tividenofusp Alfa (DNL310) vs Idursulfase in Pediatric and Young Adult Participants With Neuronopathic or Non-Neuronopathic Mucopolysaccharidosis Type II

This study has been transitioned to CTIS with ID 2024-510990-21-00 check the CTIS register for the current data. The co-primary objectives are: To evaluate the CNS activity of DNL310 vs idursulfase as measured by the cerebrospinal fluid (CSF)…

Improving executive functioning in patients with Mild Cognitive Impairment by transcranial alternate current brain stimulation

We hypothesize that synchronous tACS in the theta range will cause an enhancement of fronto-parietal brain synchronization and improvement in EF of MCI patients.We aim to apply tACS in the theta range over the left frontal and parietal areas of…

RE-SPECT CVT: a randomised, open-label, exploratory trial with blinded endpoint adjudication (PROBE), comparing efficacy and safety of oral dabigatran etexilate versus oral warfarin in patients with cerebral venous and dural sinus thrombosis over a 24-week period

See protocol sectie 2.1 & 2.2

Randomized, double-blind, double-dummy, active controlled, multicentre, non-inferiority phase-III study to compare the pharmacokinetics, efficacy and safety of gabapentin liquid formulation to tramadol in children from 3 months to less than 18 years of age experiencing moderate to severe chronic neuropathic or mixed pain.

Primary objectiveThe primary objective of this study is to assess the efficacy of gabapentin relative to tramadol for the treatment of moderate to severe chronic neuropathic or mixed pain in children from 3 months to less than 18 years of age.…