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The relationship between pain and cognitive functioning, of patients with neurodegenerative diseases such as Parkinson's disease, Multiple Sclerosis and Huntington's disease
Substudy: The relationship between pain, cognitive functioning, and motor activity in patients with multiple sclerosis

Various brain areas play a crucial role in both pain and cognition, supporting the existence of a close relationship between pain and cognition. Consequently, it is important to examine whether pain experience changes at the moment the patient shows…

Neuroinflammatory consequences of chronic repetitive head injury in Muay Thai boxing

The primary objective is to determine whether neuroinflammation is present in subjects who have been exposed to chronic repetitive head injury during Muay Thai boxing, using [11C]-PK11195 PET.

PET imaging of neuroinflammation in mild traumatic brain injury

The primary objective of this study is to determine if neuroinflammation is present in patients with mild traumatic brain injury, using [11C]-PK11195 PET. The secondary objective is to determine if there is a correlation between [11C]-PK11195…

The effects of nanoparticles and ambient particles on brain function using quantitative electro-encephalography (QEEG) in healthy volunteers

To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…

Clinicopathological MRI and CSF correlates of iron accumulation, neurodegeneration and neuroinflammation in Huntington*s disease.

1. To quantify brain iron accumulation in patient with HD using quantitative susceptibility mapping (QSM) at ultrahigh field (7T) as compared to healthy controls (case-control design).2. To link QSM results with specific and well-known clinical CSF…