55 results
To report on (the age-dependency of) the long-term effect(s) of chronic SSRI treatment during adolescence or adulthood on the outgrowth and function of the 5-HT system, using state-of-the-art Magnetic Resonance Imaging (MRI) techniques and other,…
The primary objectives are defined according to a hierarchical design: i) to tailor and apply multi-parametric, functional MRI techniques to identify cerebral abnormalities (cerebral biomarkers) in DM2 and MetS; ii) to investigate which cerebral…
Addictive disorders affect a steady proportion of the population, and result in significant negative personal consequences(e.g. loss of jobs, psychosocial problems) and costs to society (absence from work due to hangover, treatment costs).GHB is…
The primary objective of this study is to evaluate neurophysiologic changes of the pain centres of the brain (the differences in particular in the thalamus, primary and secondary somatosensory cortex, insula, anterior cingulate cortex and the motor…
The main goal of the study is to develop and validate a device that provides an objective measure of degradation of motor performance in elderly people. The device will assist to diagnose neurodegenerative disorders in the elderly at an early stage…
The primary aim is to investigate the effects of attentional focus manipulation on the performance of a repetitive leg movement task under single and dual-task conditions in ABI patients. Furthermore, it will be investigated to what extent the…
Primary Objective: Our main goal is to contribute to the identification of an attentional profile of the paediatric TBI population, by analysing the quality and efficiency of alerting, orienting, executive and sustained attentional functioning. This…
With this research we intend to fill the gap described in the previous chapter by:1) Detecting functional network changes in several causes of early-onset dementia and to characterize the specific changes for each dementia cause.2) Relating specific…
Primary objective of the study: 1. To report on the age-dependency of the effect(s) of MPH or SSRI treatment on the outgrowth of the DA and 5-HT systems, respectively, using state-of-the-art Magnetic Resonance Imaging (MRI) techniques
Primary objective: The ultimate goal is to achieve a more sensitive method for detecting malformations of cortical development. This encompasses two steps: the development of the method and the assessment of the sensitivity and specificity of the…
The objective of the study is to investigate the effects of bright light combined with physical activity during the morning on subjective and objective outcomes related to sleep-wake cycle and the rest-activity rhythm in persons with MCI, aged 65…
The purpose of this research line is to assess whether measures acquired with advanced MR neuroimaging can be used as neuropathological markers for the early diagnosis of dementia and differentiation between AD and FTD. For each project, the…
Addictive disorders affect a steady proportion of the population, and result in significant negative personal consequences (e.g. loss of jobs, psychosocial problems) and costs to society (absence from work due to hangover, treatment costs). GHB is…
The main, primary objective of this study is identification of the molecular mechanisms that regulate structure and function of red blood cells in patients with neurodegeneration accompanied by the presence of abnormal red blood cells (…
Primary Objective: To examine which subregions of the hippocampal formation on 7 Tesla MRI are most affected in patients with early Alzheimer*s disease compared with older persons with normal cognition. Secondary Objectives:a) To explore risk…
In this study, we will systematically investigate the influence of distractors on target processing in patients with lesions to the frontal, parietal and occipital system. This will be measured by eye movements. Furthermore, prism adaptation will be…
The first line of research encompasses the frequency, severity, and (dis)similarities of perceptual and attentional impairments in near and far space. Differential impairments of near and far space processing are more likely to be found when spatial…
To compare neonatal mortality and short-term (advanced MRI indices of structural brain injury at 40 weeks* GA) and long-term neurodevelopmental outcomes (Bayley scales of infant development III [BSID-III] at 24 months) between two groups of very…
The main question in the study isHow do moderately preterm infants and their parents differ from term, as well as extreme preterm infants in (a) development and self regulation skills of the infants, (b) interaction patterns and relationship between…
Cytotoxic treatment may lead to long-lasting brain damage that can result in persistent cognitive changes and accelerated cognitive decline at an older age. The proposed study will investigate whether chemotherapy causes brain changes different from…