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Prevention of multiple pregnancies in couples with unexplained or mild male subfertility.

1. To prevent multiple pregnancies and the concomittant neonatal mortality and morbidity while retaining acceptable delivery rates in couples with unexplained subfertility or mild male subfertility and poor fertility prospects. 2. To assess the…

Tactile stimulation to improve spontaneous breathing in neonatal resuscitation

The objective of this study is to compare the direct effect of repetitive tactile stimulation versus standard stimulation on the respiratory effort of preterm infants during stabilisation at birth. The most ideal comparison would be to compare…

Pessary or Progesterone to Prevent Preterm delivery in women with short cervical length.

To compare the effectiveness of progesterone and cervical pessary in the prevention of preterm birth in women with singleton and twin pregnancies and a short cervix.

Comparing CPAP Titration Strategies in very preterm infants at birth

To compare the effect of a HCPAP with LCPAP on oxygenation in the first 5 minutes during stabilization in preterm infants at birth.

Physiological-based cord clamping in preterm infants: a multicentre randomised controlled trial.

To compare the effect of umbilical cord clamping after cardiopulmonary stabilisation (Physiological Based Cord Clamping; PBCC) to standard care (Time Based Cord Clamping; TBCC) on intact survival and health care costs in preterm infants.

Delayed Umbilical Cord Clamping Amphia Study - ALAAF study

This study will evaluate if neonatal effects as described in previous studies are seen in delayed umbilical cord clamping in caesarean sections. Moreover, we will review the maternal effects compared to conventional cord milking in caesarean…

Physiological-based cord clamping for infants with congenital diaphragmatic hernia: a multicentre randomised controlled trial

Primary Objective: To evaluate whether PBCC results in a reduced incidence of pulmonary hypertension in infants with CDH 24hrs after birth.Secondary Objectives: To measure and monitor physiological parameters during transition to provide information…

Pessary or Cerclage to prevent preterm delivery in women with short cervical length with and a history of preterm birth.

To evaluate whether cervical pessary can replace cervical cerclage in women with previous preterm birth and a short cervix or in women with a history of multiple preterm births in terms of effectiveness and costs

High versus low initial oxygen to improve the breathing effort of preterm infants at birth

The objective of this study is to compare the direct effect of the administration of an initial FiO2 of 1.0 versus 0.3 on respiratory effort during stabilisation of preterm infants in the first 5 minutes after birth. After evaluation of the initial…

Stabilisation of preterm infants with intact umbilical cord: effectiveness study.

To test whether stabilisation of preterm infants with PBCC using the Concord is at least as effective when compared to the standard approach using the standard resuscitation table.