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Prevention of atelectasis in the preoxygenation phase: comparison of two different oxygenation strategies

To assess if preoxygenation with 100% O2 or preoxygenation with 100% O2 and PEEP are different with respect to the development of atelectasis as determined by lung computed tomography.

A multi-center, prospective, blinded validation study to assess the accuracy of a host-response based diagnostics for distinguishing between bacterIal and viral etiology in pediatric patients with lower respiratory tract infections and fever without source

To externally validate the accuracy of a host-response based diagnostics for differentiating between bacterial and viral etiology in pediatric patients aged 2 to 60 months with LRTI or FWS.

AMBITION: A Randomised, Multicenter Study of First-Line Ambrisentan and Tadalafil Combination Therapy in Subjects with Pulmonary Arterial Hypertension

The primary objective of this study is to compare the two treatment strategies; first-line combination therapy (ambrisentan and tadalafil) versus first-line monotherapy (ambrisentan or tadalafil) in subjects with PAH. This will be assessed by time…

Symptomatic treatment of pollen related allergic rhinoconjunctivitis and the relation with asthma with children in the General practice

This study consists of two research questions: 1. Which treatment (INCS on daily bases versus INCS on demand or versus oral antihistamines on demand) is most effective in reducing nasal symptoms and ocular symptoms in children with mild to moderate…

A 52-week treatment, multi-center, randomized, doubleblind, double dummy, parallel-group, active controlled study to compare the effect of QVA149 (indacaterol maleate / glycopyrronium bromide) with salmeterol/fluticasone on the rate of exacerbations in subjects with moderate to very severe COPD (CQVA149A2318)

Primary objective: To demonstrate that QVA149 (110/50 *g o.d.) is at least non-inferior to salmeterol/fluticasone (50/500 *g b.i.d.) in terms of rate of COPD exacerbations.Secondary objectives: Superiority in terms of exacerbation rate. Time to…

AssessmenT of smalL Airways involvemeNT In aSthma (ATLANTIS)

Major objectives:- To determine the role of small airways abnormalities in the clinical manifestations of asthma;- To evaluate which (combination of) clinical methods best assesses the abnormalities of small airways and large airways disease in…

Imaging of Ventricular Reversed Remodeling after Double Lung Transplantation in Patients with Pulmonary Arterial Hypertension

To study remodeling patterns of the left and right ventricle in patients with pulmonary arterial hypertension who underwent lung transplantation, using cardiac magnetic resonance imaging.

Caffeine treatment for stimulation of spontaneous breathing in preterm infants at birth

To investigate the direct effect of caffeine on the respiratory effort of the preterm infant at birth.

central airways and lung volume assessment by Magnetic Resonance Imaging in children

Primary objective: to evaluate the image quality between the two protocols using Signal to Noise Ratio (SNR) measurements Secondary objectives: 1) test if measurements of lung volume and central airways dimensions using MRI are related to validated…

Cine-MRI to diagnose glossoptosis in Robin Sequence (RS)

Aim of total study:Diagnosing all components of RS in an objective mannerAim of present substudy:Increasing the reliability and decreasing the burden of the method with which glossoptosis can be determined in newborns with RS

A multicenter study evaluating the diagnostic value for vascular abnormalities of High Definition Bronchoscopy when combined with i-scan Imaging Technology compared to High Defintion Bronchoscopy alone

Primary objective:Determing the positive predictive value and diagnostic yield of HD+ i-scan bronchoscopy for vascular pattern detection .Secondary objectives:1. To investigate the correlation of vascular abnormalities with histology2. To…

Troponin Activator to Restore Diaphragm Function in COPD

PRIMARY OBJECTIVE:To determine the contractile strength of diaphragm fibers of COPD patients before and after in vitro exposure to CK-107. SECONDARY OBJECTIVE:To determine the contractile strength of latissimus dorsi fibers of COPD patients before…

Multicenter 3-arm trial to evaluate the efficacy and safety of Pasireotide LAR or Everolimus alone or in combination in patients with well differentiated neuroendocrine carcinoma of the lung and thymus -LUNA Trial

To evaluate the efficacy of pasireotide LAR and everolimus alone or in combination in progressive patients with a well differentiated neuroendocrine tumor of the lung or thymus.

MOSAIC study:
MOdel to Study upper Airway Immunity upon Cholera vaccination

To investigate whether raw milk is able to enhance the upper airway immune response as induced by oral cholera vaccination.

The role of innate lymphoid cells in asthma and rhinovirus-induced asthma exacerbations

This study aims to determine whether the ILC populations differ in the lungs of different phenotypes of asthmatic patients and healthy subjects and how these cells are regulated by bronchial epithelial cells. Furthermore we want to study how this is…

Fatigue after prophylactic cranial irradiation in stage I-III small cell lung cancer patients: is there a substrate on functional magnetic resonance imaging of the brain?

To asses the effect of PCI on the brain with functional MRI (fMRI) and diffusion tensor imaging (DTI)-MRI and assess whether there is a correlation with patient-experienced fatigue.

It's LiFe! Innovative monitoring and personalised feedback as a self-management tool in disease management programmes for people with COPD and/or type 2 diabetes; a randomised controlled trial

The main objective of this study is to measure the effects of the monitoring and feedback tool embedded in a Self-management Support Program on physical activity. The secondary objective is to measure the effect on self-efficacy, quality of life and…

The muscle activity of the diaphragm and intercostal muscles in acutely dyspneic children during hospitalization, before and after treatment with salbutamol

In the present study we want to examine the effect of salbutamol on the muscle tone of the diaphragm. We also want to examine the correlation between muscle tension measured by EMG and the Clinical Asthma Score. To include the children that come to…

Skeletal Muscle Metabolism during Rest, Exercise and Recovery in Patients with Cystic Fibrosis and Healthy Controls

To compare the oxygenation and oxidative metabolism in skeletal muscles of patients with CF with healthy controls to provide insight in the metabolism in patients with CF.

Cisplatin or Cetuximab and conventional versus redistributed radiation for advanced head and neck cancer

This Phase II trial aims to:1 Test the predictive value of Zr89 Cetuximab uptake in vivo for treatment specific outcome 2 Explore the impact of dose redistribution on loco-regional control and disease free survival.If individualized treatment…