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Mucoviscidosis and Inflammation, Variability through Exercise and Training: Maximal exercise test

Primary objective: *What is the effect of an incremental maximal exercise test on inflammation in patients with cystic fibrosis and in healthy people?*Secundary objectives:- What are the differences in basal immune values between HP and CF patients…

Long Term Administration of Inhaled Mannitol in Cystic Fibrosis - A Safety and Efficacy Study

The purpose of this study is to examine the efficacy and safety of 26 weeks treatment with inhaled mannitol in subjects with cystic fibrosis. Previous studies with inhaled mannitol have demonstrated improvements in lung function, mucociliary…

A multicenter, randomized, 52-week, double-blind, parallelgroup, active controlled study to compare the efficacy and safety of QVM149 with QMF149 in patients with asthma

The purpose of the trial is to evaluate the efficacy and safety of two different doses of QVM149 (QVM149 150/50/80 *g and QVM149 150/50/160 *g via Concept1) over two respective QMF149 doses (QMF149 150/160 *g and QMF149 150/320 *g via Concept1 in…

A DOUBLE-BLIND RANDOMISED 2-ARM, 2-PERIOD CROSSOVER STUDY TO ASSESS THE SIMILARITY OF SAFETY AND PHARMACOKINETICS OF JHL1922 AND PULMOZYME® AFTER SINGLE AND REPEATED ADMINISTRATION IN HEALTHY SUBJECTS

The purpose of this study is to investigate how safe the new compound JHL1922 is when it is administered to healthy subjects. JHL1922 has not been administered to humans before, but it has been previously tested in the laboratory. In this study, the…

A single dose two-way cross-over study in healthy participants to compare the pharmacokinetics (PK) of salbutamol administered via metered dose inhalers containing propellants HFA-152a and HFA 134a

Certain drugs are administered by using an inhaler (puffs). An inhaler may contain propellant to get the right amount of the medicine into the lungs in the right way. Some of the propellants used in inhalers are greenhouse gasses and are therefore…