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Do microRNAs control inflammatory mediator production by airway epithelial cells from patients with asthma and COPD?

Besides more basic research into which RNA-binding proteins and microRNAs regulate the expression of inflammatory mediators in airway epithelial cells, we will also assess these proteins and microRNAs in airway epithelial cells from patients with…

The effects of nanoparticles and ambient particles on brain function using quantitative electro-encephalography (QEEG) in healthy volunteers

To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…

3TR - ABC (Asthma Biologics Cohort) study and AIR-Bio-OCT study
A part of the 3TR (Taxonomy, Treatment, Targets and Remission) Consortium for the identification of the molecular mechanisms of non-response to treatment, relapses, and remission in autoimmune, inflammatory, and allergic conditions

The overall aim of the study is to improve personalized medicine for patients with severe asthma through the investigation of possible immunological mechanisms responsible for non-response or incomplete response to biological treatments.2.1 3TR -…

Remimazolam for long-term sedation during invasive mechanical ventilation in critically ill patients

To elucidate whether a sedation regimen with remimazolam can reduce the ICU length of stay in critically ill patients with renal failure, compared to patients treated with a sedation regimen with midazolam.