34 results
Our primary objective is to identify which intrinsic defect in Tregs is crucial for sarcoidosis pathology. To this end we will examine the genetic and functional properties of Tregs in the peripheral blood and at the site of disease, i.e. the lung…
The primary objective is to compare the incidence of patient-ventilator-asynchrony during paediatric mechanical ventilation using ventilator waveforms with PVA detected by using the ventilator waveforms in combination with diaphragm and intercostal…
The objective of this crossover study and randomized controlled trial is to compare ΔP levels during INTELLiVENT®-ASV with conventional lung protective ventilation in patients with moderate or severe ARDS.
The main objective of our Center for Translational Pediatric Pulmonology (CTPP) is to establish models of bronchial epithelial function in children, by (1) epithelial organoid cultures derived from bronchial epithelial cells; (2) bronchial brushings…
Primary Objective: To identify the variability in the circulation of the number of patrolling monocytes and their expression of CX3CR1 obtained from adult ZZ-AATD patients compared to spouse controls.Secondary Objective(s): (1) To identify if low…
To compare young and old COPD immunologically, physiologically, risk factors, patient behaviour and quality of life.
Primary Objective: The primary objective of this study is to assess lung volume measured by EIT and minute ventilation measured by the ventilator during CMV and FCV at the ICU. This will allow for an adequate powercalculation for future studies.…
Zie pagina 14 research protocol
1. To compare the need for (prolonged) chest tube drainage in two different diagnostic strategies to acquire lung tissue in ILD (bronchoscopic cryobiopsy followed on indication by surgical lung biopsy (intervention) versus immediate surgical lung…
to assess the pulmonary toxicity in patients treated with cyclophosphamide compared to a control group
1) To investigate what mechanisms underlie the phenomenon of deventilation dyspnoea in COPD patients. 2) To investigate how the change in electrical impedance, measured with electrical impedance tomography (EIT), is related to the change in…
The overall aim of the study is to improve personalized medicine for patients with severe asthma through the investigation of possible immunological mechanisms responsible for non-response or incomplete response to biological treatments.2.1 3TR -…
The aim of the EXACT@Home study is to further improve the assessment of treatable traits in patients with difficult to treat to severe asthma using ehealth before considering treatment with biologics.
Remimazolam for long-term sedation during invasive mechanical ventilation in critically ill patients
To elucidate whether a sedation regimen with remimazolam can reduce the ICU length of stay in critically ill patients with renal failure, compared to patients treated with a sedation regimen with midazolam.