264 results
PROUD is a multicentre prospective study, using clinical factors in combination with additional tests with the aim to clarify more about the aetiology and pathogenesis of MS.
Are changes in cognitive functioning related to structural changes in the brain in patients with type 1 diabetes mellitus. How are these changes related to diabetic complications like duration of chronic hypoglycaemia, disease duration and presence…
The primary aim of current study is to assess the effect of different cooling times on the efficacy of scalp cooling, thereby improving the results of scalp cooling in the high dose 5-Fluorouracil - Epirubicin - Cyclophosphamide (FEC) regimen. A…
PrimaryTo investigate whether 5 years of extended adjuvant treatment with letrozole results in an improved DFS compared to 2.5 years treatment in patients with early breast cancer previously treated with endocrine agents for 5 yearsSecondaryTo…
In this study the prevalence and kind of sexual and psychosexual problems will be assessed. Psychological well being is studied as well
We intend to study the role of fronto-striatal circuitry and cognitive control in the inflexible behaviour that is a defining feature of autism.
To obtain insight in the role of the innate immune response, especially Type 1 interferons, in the pathogenesis of RSV LRTI. New techniques are used to unravel the local (nasopharyngeal) immunological milieu during viral LRTI. The hypothesis is that…
The purpose of this project is to perform a randomized trial comparing BARRX ablation with endoscopic surveillance for patients with a Barrett*s esophagus containing low-grade dysplasia. This study will also assess the effect of RFA ablation in…
zie bovenstaand
One cycle of IVF-eSET followed by transfer of frozen embryos is at least as effective as three cycles of IUI-COH in terms of ongoing pregnancy. Multiple pregnancies however can largely be prevented by treating women with IVF-eSET.
The Rotterdam Daily Exercise Project leads to less overweight, improved fitness, healthier food habits and healthier exercise habits.
Life review therapy will have a positive effect on the level of depressive symptoms of nursing home inhabitants.
Primary 1. An immediate invasive approach (immediate angiography and revascularization when appropriate) results in a reduction of the combined incidence of death, re-infarction or recurrent ischemia at 30 days follow-up. Secondary 1. An immediate…
Objective: The primary objectives of this study are comparing the duration of recurrence free survival following completion of treatment between the 2 study arms. Secondary objectives of this study involves toxicity and morbidity, quality of life,…
Registry is the core study of the European Huntington*s disease Network (EHDN). The aim of the Registry study is to collect prospective data on the phenotypical characteristics of Huntington's disease (HD) mutation carriers regardless of…
The primary objective of this study is to establish the sensitivity and specificity of an oral uracil loading test as a potential screening tool for DPD deficiency
To compare the efficacy of erythropoietin beta administered weekly using an early start approach (Hb * 7.2 mmol/l) with standard starting approach (Hb * 6.2 mmol/l) in subjects with lymphoproliferative malignancy, receiving chemotherapy during a 16-…
In this study, we will test the efficacy of SFT in forensic patients with 4 severe personality disorders -- Antisocial, Narcissistic, Borderline, and Paranoid Personality Disorders -- in ameliorating personality disorder symptoms and reducing risk…
Objectives:Phase 1b: To determine the maximum tolerated dose (MTD) (up to 8mg/kg/day) through safety and tolerability of multiple doses of AMG 951 administered by intravenous (IV) infusion to subjects with NSCLC in combination with chemotherapy and…
the investigation and evaluation of certain serummarkers for inflammation and tumoractivity during the followup of colorectal neoplasms, and the applicability of these markers during the followup of these patients or the evaluation of the effect of…