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Evaluation of the oral uracil loading test as a sensitive, simple and cheap method to detect DPD deficiency.

The primary objective of this study is to establish the sensitivity and specificity of an oral uracil loading test as a potential screening tool for DPD deficiency

A Multicenter, Open Label, Randomized Study of AMG 951 in Subjects with Previously Untreated Stage IIIb/IV Non-Small Cell Lung Cancer (NSCLC) Treated with Chemotherapy with or without Bevacizumab

Objectives:Phase 1b: To determine the maximum tolerated dose (MTD) (up to 8mg/kg/day) through safety and tolerability of multiple doses of AMG 951 administered by intravenous (IV) infusion to subjects with NSCLC in combination with chemotherapy and…

A Safety and Efficacy Study of SCH 503034 in Previously Untreated Subjects With Chronic Hepatitis C (CHC) Infected With Genotype 1

The primary objective of this study is to evaluate the efficacy of SCH 503034800 mg TID PO in combination with PegIntron 1.5 *g/kg QW SC plus ribavirin (800 - 1400 mg/day) in previously untreated adult chronic hepatitis C (CHC) subjects infected…

A Phase II multicenter study to assess the tolerability and efficacy of the addition of Bevacizumab to standard induction therapy in AML and high risk MDS above 60 years, HOVON 81

Evaluation of the safety and tolerability of Bevacizumab added to standard induction chemotherapy. Evaluation of the effect of Bevacizumab on the CR rate

RANDOMIZED PHASE II/III STUDY OF INTENSIFIED ALKYLATING AGENT CHEMOTHERAPY WITH PERIPHERAL BLOOD PROGENITOR CELL SUPPORT IN THE PREOPERATIVE CHEMOTHERAPY OF BREAST TUMORS THAT ARE DEFICIENT FOR HOMOLOGOUS RECOMBINATION.

Nearly all patients who die from breast cancer die from the consequences of distant metastases. Adjuvant chemotherapy, either administered before or after surgery, has been shown to reduce the risk of metastases and death. Four main groups of…

Protect: Clinical evaluation of pacing during the onset of revascularization. Clinical feasibility study

The purpose of this study is to determine whether the application of ventricular pacing during PCI for AMI can protect the human heart from damage as a result of ischemia/reperfusion injury

Dialectical Behavior Therapy for patients with antisocial personality disorder: a pilot study in FPC Oldenkotte

The objective of the study is to find out the possible effects of the DBT program for antisocial patients and the best instruments to measure these effects. It is a try-out of the program and it will be modified if necessary. The longer term aim is…

Preoperative short-term radiotherapy for primary resectable rectal cancer:
Accelerated once daily (5x5Gy)
versus
accelerated hyperfractionated twice daily (12x2,5Gy b.i.d.)
(ONCE-TWICE trial)
A phase II single-blinded multi-institutional randomised study

The objective of this prospective randomised trial is to test the hypothesis that hyperfractionated short course preoperative radiotherapy (12 x 2.5 Gy twice daily) leads to less radiation-induced bowel toxicity compared to the standard…

Randomized phase II study of brostallicin (PNU-166196A) versus doxorubicin as first line chemotherapy in patients with advanced or metastatic soft tissue sarcoma

The objective of this trial is to evaluate the activity and safety of Brostallicin used as first line chemotherapy in patients with advanced or metastatic soft tissue sarcoma.

Unraveling the effects of rhythmic external cueing on mobility: synchronisation and use of alternative circuitry in the parkinsonian brain.

To identify neurophysiological mechanisms (e.g. synchronisation / desynchronisation) and brain areas (i.e. localization) involved in the performance of cued movements in PD.

The effect of iontophoresis and surfactant on transdermal apomorphine micro-emulsion treatment in patients with Parkinson's Disease

- Is the apomorphine micro-emulsion effective and safe?- Does iontophoresis improve the clinical effect and safety of the micro-emulsion?- Does surfactant improve the effectiveness of the micro-emulsion with iontophoresis without changing the safety

Influence on brain perfusion and metabolism through pharmacologic agents

In this study we would like to investigate whether cerebral perfusie and cerebral metabolism can be influenced with pharmacological agents in patients with MS and in healthy control persons. Cerebral perfusion and cerebral metabolism wil be measured…

Phase II multi-centric, randomised, open-label, parallel-group study to assess the non-inferiority of Pamorelin® 11,25 mg SC injected versus Pamorelin® 11,25 mg IM injected in patients suffering from advanced prostate cancer

Primary Study ObjectiveTo assess the non-inferiority of the 12-week triptorelin formulation Pamorelin® 11,25 mg administered via subcutaneous (SC) injection as compared to Pamorelin® 11,25 mg administered via registered intramuscular (IM) injection…

An international, randomised, open label trial comparing a rituxmab based regimen with a standard cyclophosphamide/azathioprine regimen in the treatment of active, 'generalised' ANCA associated vasculitis

To assess the rates of preliminary response and sustained remission of AASV following rituximab (on the basis of former studies, 86% sustained remission expected with rituximab compared to 75% in control group).To assess safety of a rituximab…