206 results
Our main objective is to conduct a pilot study testing the applicability and face/external validity of the battery in a young-onset PD cohort, alongside age-matched healthy controls. We aim to gain deeper insights into the complex interrelationships…
The Check@Home consortium aims to set up a roadmap and infrastructure for a (cost-)effective program to early detect atrial fibrillation and chronic kidney disease (defined by elevated albuminuria) in the general population. Furthermore, the project…
The following questions will be addressed in the PARASOL study• What is the effect of plication or non-invasive mechanical ventilation on the EQ-5D-5L? o The pilot study is needed as we do not know the clinical relevant effect of both therapies on…
To assess whether adjuvant chemotherapy can be safely omitted in patients with pathological stage I (pT1a/b/cN0) TNBC and a high sTIL score (defined as >=50% for patients <40 years at the time of TNBC diagnosis; >=75% for…
This study has been transitioned to CTIS with ID 2024-516196-32-00 check the CTIS register for the current data. To investigate whether (neo)adjuvant systemic treatment of intensified alkylating chemotherapy with peripheral stem cell rescue (mini-…
We aim to investigate in an RCT the (cost-)effectiveness of CM, compared with usual care CBT in the treatment of CUD in youths aged 16 to 22 years. Both outpatient treatments are provided for 12 weeks.PRIMARY STUDY QUESTION:1. What is the efficacy…
Regarding the current recommended once daily dosing of oral iron (with probably less side effects than with a 3 times daily dose), and the decrease of hepcidin in patients on immunosuppressive medication, we hypothesize that patients with mild to…
To implement and assess the feasibility, efficacy and safety of bariatric surgery in adolescents with severe obesity together with a multidisciplinary care pathway around the procedure.
The GO TEST OVERTURE study aims to demonstrate the superiority of the Treat to Target management strategy over a Treat to Avoid Symptoms approach in terms of clinical remission of gout symptoms.
Primary Objective: to determine whether telemonitoring through SpA-Net, in combination with patient-initiated care, leads to less outpatient visits compared with standard care. Secondary Objective(s): to determine whether telemonitoring through SpA-…
Primary objectives: - To assess safety and feasibility of neoadjuvant nivolumab +/- domatinostat +/- ipilimumab- To identify pathologic response rates of nivolumab +/- domatinostat +/- ipilimumabSecondary objectives: - To describe all grade…
The main objective of this study is to develop and investigate the (cost-) effectiveness of a pharmacist-led personalised intervention, with E-Health components, to analyse and improve medication adherence in people with T2DM, who are non-adherent…
Aim: to develop, implement and evaluate COMBO to improve SDM during the treatment trajectory of TC patients in situations when clear cut recommendations cannot be made either because the benefits closely balance with risks, or because this balance…
The primary objective of the present study is to assess the added values of using tele-rehabilitation services, combined with caregiver mediated exercises to improve the level of self-reported mobility at home. Secondary objectives are to assess the…
To assess the effectiveness and cost-effectiveness of personalized orthotic care to improve functioning in patients with NMD compared to standard orthotic care.
We will assess the (cost-)effectiveness of implementing two interventions in the birth centre setting:1. TcB measurement as a non-invasive screening tool to identify jaundice.2. Application of phototherapy in the birth centre.We hypothesise that…
To provide high-quality remote care to patients with type 2 diabetes, using an eHealth platform with support from a medical service center. The present study is optimisation and implementation research. Notably, the aim is not implementation but…
The main objectives of this study are to investigate to what extent:1) VRT and MT can contribute to pain reduction compared to patients who receive no VRT and MT intervention during complex wound care; and2) VRT can contribute to pain reduction…
The objective of this study is to assess the non-inferiority of an internet-based HIV PrEP-service and reduced frequency of monitoring visits in comparison to standard-of-care at the GGD.
This study has been transitioned to CTIS with ID 2024-513519-28-00 check the CTIS register for the current data. Primary objective • To compare the event-free survival (EFS) of neoadjuvant ipilimumab + nivolumab (followed by adjuvant nivolumab or…