206 results
This study has been transitioned to CTIS with ID 2024-515514-40-00 check the CTIS register for the current data. The primary objective is to investigate the rate of pathological responses following different neoadjuvant immunotherapy combinations in…
The primary objective of the MENTUPP research project is to improve mental health in the workplace by developing, implementing and evaluating the effectiveness of a multicomponent intervention (MENTUPP) targeting mental health difficulties (non-…
This study has been transitioned to CTIS with ID 2024-511877-31-00 check the CTIS register for the current data. The primary objective is to demonstrate non-inferiority of experimental esketamine administration of 6x 1 day per 2 weeks (in total 3…
The aim of the study is to improve case finding of advanced cases of NAFLD (>=F3 fibrosis), whilst simultaneously reducing unnecessary referrals for mild cases (NAFLD-related complications, and to assess the cost-effectiveness of the…
The objective of this study is to assess the clinical effectiveness of the PatientCoach mHealth app with and without home monitoring devices on sustained asthma control after AACT, in patients with severe or uncontrolled asthma.
In this randomized controlled phase III study we will evaluate whether TIL infusion preceded by non-myeloablative chemotherapy and followed by high dose bolus interleukin-2 can result in an improved progression free survival when randomly compared…
The above mentioned developments are subject to the I CARE study. We hypothesize that general practitioner (GP) involvement improves both aftercare and preventive care resulting in improved quality of life and patients* satisfaction. Furthermore, a…
To determine the (cost)effectiveness of OTHER (Occupational Therapy at Home E-Rehabilitation), as compared to usual OT, on improving the self-perceived performance in daily activities of community-dwelling older persons post-stroke over a 24-week…
To set up a cohort of breast cancer patients, collecting information on patient characteristics, short and long-term clinical and patient reported data, and to compare outcomes with a healthy refrence population. whichThe cohort will also serve as…
Objective: Is proactive integrated care costeffective and does it result in better patients experience than usual care after 12 months for patients with problems on multiple life domains?This study will focus on measuring the changes in the…
The following questions will be addressed in the PARASOL study• Is the proposed study design feasible?,We will set up the study as a randomized pilot study to evaluate if patients are willing and able to participate in a randomized trial, i.e. are…
Primary objective: To investigate if the presence of aneurysm wall enhancement predicts aneurysm instability in the long-term. Secondary objective: To investigate if the absence of aneurysm wall enhancement predicts aneurysm stability in the long…
To study if a blended personalized periconception lifestyle care approach aimed at women with a high risk for pregnancy complications who are contemplating pregnancy or already pregnant (*12 weeks) can significantly reduce Lifestyle Risk Score.
Examining the applicability of a fieldable serological point of care serological test Biozek and Point of care molecular Fluorescent in Situ Hybridization (FISH) technology by Biotrack for the usage of decision making, containment and management of…
We hypothesize that the follow-up and aftercare of prostate cancer in the Netherlands can be led by the GP. We hypothesize that GP-led recurrence detection programme leads to at least equal detection of recurrences as the current follow-up in…
To evaluate the effect of lidocaine temperature on pain perception during infiltration for upper blepharoplasty.
The aim of this study is to obtain answers to the following main questions:1. Are delay discounting, time estimation and PTSD influenced by treatment?2. Do patients differ from healthy controls in delay discounting and/or time estimation ability? In…
Primary objective:To assess the overall feasibility of undertaking a definitive randomized controlled trial on the effects of tailored inhaler education by the GP/nurse supported by a smart spacer, in primary care treated adults with asthma.…
To assess the efficacy, safety and cost-effectiveness of the CYP2C19 genotype guided antiplatelet treatment strategy, using clopidogrel or prasugrel/ticagrelor.
Physical ExeRcise Following Esophageal Cancer Treatment (PERFECT) Study: a randomized clinical trial
Primary Objective: - To investigate whether a 12-week exercise intervention increases HRQoL in patients after curatively intended EC surgery compared to a usual care control group.Secondary Objective(s): - To investigate whether a 12-week exercise…