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EMDR with traumatized adolescents with a major depressive disorder

The aim of this study is to investigate the effectiveness of EMDR with traumatized adolescents (12-18 years) with major depressive disorder.

Effectiveness of a 12-week self-myofascial release therapy on pain and tendon stiffness in active recreational runners with self-reported Achilles tendon complaints

The purpose of this study will be to evaluate and compare the effectiveness of a multifocal SMR treatment on pain and stiffness compared to ECC in active recreational runners with self-reported Achilles tendon complaints.Research question: Is a 12-…

A single dose, randomized, four-way cross-over, bioavailability and food interaction study of PedPRM (Pediatric Prolonged Release Melatonin, Neurim Pharmaceuticals Ltd) and Circadin® tablets in healthy male and female volunteers.

Primary Objective- To demonstrate dose proportionality between 1 mg and 5 mg of PedPRM (Neurim Pharmaceuticals Ltd.) following a single oral dose in healthy male and female volunteers (treatment A and C), under fed conditions.Secondary Objectives-…

Magnetic Marker Localization for breast cancer surgery: An exploratory study

The purpose of this clinical study is to investigate surgical usability, patient-reported outcomes and effectiveness of the MaMaLoc technique and compare it with WGL.

Evaluation of boiled vs raw eggs for stimulating post-exercise muscle protein synthesis

Looking into the effects of raw vs boiled eggs vs isocaloric low-protein meal on muscle growth.

Intra-articular injection of stromal vascular fraction from adipose tissue in osteoartritis of the temporomandibular joint

The main objective is to objectify if the injection of SVF influences the pain of the TMJ during movement. Secondary objectives are pain during rest, maximum mouth opening, and function evaluation.

Mandibular Advancement Device (MAD) therapy in edentulous patients with obstructive sleep apnea: dental implant fixed MADs vs. CPAP.

The main purpose of this pilot study is to assess the feasibility and potential efficacy of implant retained mandibular advancement device (MAD) therapy on a small scale in edentulous patients with mild to moderate OSA in comparison to CPAP therapy…

A randomized controlled trial evaluating the additional effect of topical coal tar to a topical corticosteroid regimen in patients aged >16 years of age with moderate-severe atopic dermatitis

To evaluate the additional effect of coal tar treatment to a corticosteroid regimen in adults (aged >16 years of age) with moderate to severe atopic dermatitis, based on the percentage change in Eczema Area and Severity Index (EASI) at week 2…

Effect of administration of single dose Histidine-Tryptophane-Ketoglutarate (HTK) cardioplegia solution on serum sodium concentration, osmolarity and acid-base balance.

To analyse serum sodium concentration, serum osmolarity and arterial bloodgas at different times before and after administration of HTK solution, to get more insight of the impact of this solution on these biochemical parameters and to improve our…

Non-invasive assessment of lung remodeling in patients with idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) using [11C]-Nintedanib or [18F]-FLT PET imaging.

To investigate whether enhanced expression of growth factor receptors (FGF-R, PDGF-R and VEGF-R) and increasedvascular cell proliferation in the lung of IPF or PAH patients can be assessed using [11C]-Nintedanib or [18F]-FLTPET/CT imaging.

Long-term efficacy and safety of microwave ablation in the treatment of mild axillary hidradenitis suppurativa: a randomized intra-patient controlled trial

Primary objective: To prospectively evaluate the lesion (AN-)count, i.e. abscesses, inflammatory nodules, and draining sinuses, in the axilla treated with MWA compared to the untreated contralateral axilla after six months.Secondary objectives: - To…

Prevention of intimal injury during transradial coronary intervention

To prevent vessel damage of the radial artery by using the Cordis Railway sheathless guiding catheter system.

Neurotoxic adverse effects of morphine and oxycodone in continuous subcutaneous infusion for treatment of pain in terminal patients with diminished renal function: a Randomized Controlled Trial.

The primary objective of this study is to compare the prevalence of delirium between oxycodone and morphine, administered by CSCI, for the treatment of pain in dying patients with a diminished renal function.The secondary objective is to compare the…

The effect of periodontitis on innate immune activation and vascular wall inflammation in relation with atherosclerosis

The main objective of this study is to investigate whether a long lasting pro-inflammatory phenotype, the characteristic of trained immunity, is present in circulating monocytes of patients with severe periodontal disease and whether this correlates…

Blood glucose monitoring, cognition, and wellbeing in relation to food intake @ work * a pilot study

The primary objective of this pilot study is to investigate the relationship between glucose and cognition and wellbeing in an at-work setting. Additionally, this study aims to investigate the variability in intra- and inter individual glucose…

Intestinal production of Imidazole Propionate in healthy and obese subjects with or without DM2;
a pilot trial

To study the pharmacokinetics of non-reactive labelled histidine (L-HISTIDINE:HCL:H2O (D5, 98%; 15N3,98%) and the effect on intestinal imidazole propionate (IP)production in small intestine vs colon in healthy controls, metabolic syndrome and DM2…

The effect of oral ingestion of casein protein versus whey protein on plasma amino acids, satiety and anorexigenic hormones after gastric bypass surgery

To investigate whether a test meal in gastric bypass patients with supplemented casein protein results in higher concentrations of satiety-related plasma amino acids and satiety-related hormones and leads to more postprandial satiety and less hunger…

Investigation of the reliability of a manual test according the rotation of the knee

Define the normal outcome and spread of the range of motion of the knee-rotationThe outcome of the manual rotationtest of the knee compared with a rotation-device. (reliability of the test)Define inter- and intra-tester reliability of the manual…

Effects of an afternoon stroll under different light conditions on alertness, sleep quality and -perception

To investigate whether three hours of consecutive daylight and activity can affect alertness and improve night-time objective and subjective sleep.

Pilot study to determine clock-related nonvisual effects of light on alertness and metabolism

To test whether a short FD protocol can be used to test whether effects of light on alertness, sleep, metabolism and temperature are under circadian control.