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The role of inflammation in the pathogenesis of tinnitus

Primary Objective: To evaluate cytokine levels in blood samples of human subjects with tinnitus and normal hearing, compared to healthy controls.Secondary Objective(s): To evaluate complete blood count measures (neutrophil count, platelet count etc…

The Role of Clamping Before Removal of a Pneumothorax Drain Connected to a Digital Drainage System

To demonstrate that removal of drains exclusively based on digital drainage system data is non-inferior to additional clamping trials regarding recurrent pneumothorax requiring chest tube reinsertion.

Safely reduce newborn antibiotic exposure with the early-onset sepsis calculator: a cluster randomized study

The primary objective of this study is to investigate whether the use of the EOS calculator safely reduces antibiotic exposure in newborns with suspected EOS in the first 24 hours after birth compared to the current Dutch guidelines.Secondary…

Coronary and Heart Effects of Early Treatment in Familial Hypercholesterolemia

To evaluate plaque burden and characteristics in early-treated FH patients and to compare coronary plaque burden and characteristics between early- and late-treated FH patients as well as with non-FH controls.

Vegan Diets: the short-term effects on daily muscle protein synthesis rates as compared to omnivorous diets inOlder adults assessed by D2O.

To investigate the short-term effect of a vegan diet on daily muscle fractional synthesis rates in comparison to an omnivorous diet in community-dwelling older adults.

TOLERANCE: a 3 arm randomized study on healTh-related quality Of Life of EldeRly pAtients with advaNced soft tissue sarComa undergoing doxorubicin every three weeks or doxorubicin weekly or cyclophosphamide plus predniso(lo)ne treatment

Main objectiveThe primary objective of this study is to assess whether a higher HRQoL, in terms of impact of the disease and its treatment on physical and role functioning, is achieved with metronomic schedules of doxorubicin or cyclophosphamide…

Virtual Reality for Pain Relief in the Emergency Room for Reduction of Fractures and Joint Dislocations

Primary Objective: Can VR reduce periprocedural and postprocedural pain during reduction of fractures and joint dislocations in the ED? Secondary Objectives: What are the effects of VR on peri-procedural anxiety?Does the level of peri-procedural…

Establishing immunogenicity and safety of needle-free intradermal delivery by nanoporous ceramic skin patch of mRNA SARS-CoV-2 vaccine as a revaccination strategy in healthy volunteers

Primary objective - to describe immunogenicity and safety in healthy volunteers of the intradermal dermal delivery of a single fractional dose of 20µg mRNA-1273 LNP vaccine (Spikevax, Moderna) more than 3 months after primary vaccination with…

Relative bioavailability study to investigate a potential interaction between dolutegravir (DTG) and tenofovir alafenamide fumarate/emtricitabine (F/TAF) administered as paediatric tablet formulations.

Primary objectives:- To assess the relative bioavailability of TAF and TFV after a single-dose FTC/TAF 3x60/7.5 mg DT (reference TAF) compared to TAF and TFV after a single-dose FTC/TAF 3x 60/7.5mg DT in combination with a single dose of DTG 30mg as…

Comprehensive Medical and Invasive Treatment strategy for patients with significant Left Anterior Descending artery disease

The primary objective of the trial is:To assess whether a non-surgical, fractional flow reserve (FFR) and optical coherence tomography (OCT)-guided treatment strategy* has a comparable outcome (MACE) with surgical revascularization of significant…

Clincial feasibility of ROBERT-SAS in severely affected stroke patients

The primary objective of the current study is to assess the feasibility of ROBERT® -SAS training in clinical setting, in acute stroke patients, including patient and therapist perspectives

A 3-part study to investigate the safety, pharmacodynamics and pharmacokinetics of increasing doses of intravenously administered N,N-dimethyltryptamine (DMT) and deuterated DMT (CYB004) in healthy smokers and non-smokers

Part A:- Evaluate the safety of increasing doses of a single dose continuous DMT infusion over 90 minutes in healthy smokers - Characterize the pharmacokinetics of a single dose DMT administered continuously over 90 minutes in healthy smokers -…

'A clinical study of the difference in the effect of pocket-irrigation in the treatment of peri-implantitis compared to a conventional therapy, the airflow: a randomized controlled trial'

The aim of this study is to assess the effectivity of the Fluxion, in combination with Bluem (Bluem, Bluem Europe, Zwolle, The Netherlands) and in combination with demineralised water. This aims to find a minimally invasive treatment for peri-…

Dotatate to locate coronary plaques at high-risk of myocardial infarction.

Primary Objective: To assess whether patients with atherosclerosis have more uptake of 68Ga-Dotatate than patients without atherosclerosis. Secondary Objective(s): To correlate 68Ga-Dotatate uptake with the fat attenuation index (FAI), a specific…

Exploring biological measures to facilitate the discovery and development of new treatments for social and cognitive deficits in Alzheimer*s disease, schizophrenia, and major depression: replication and generalisability of the Psychiatric Ratings using Intermediate Stratified Markers (PRISM)1 study

The overall goal of the PRISM programme of research is to develop a quantitative, transdiagnostic, neurobiological approach to the understanding of neuropsychiatric disorders in order to accelerate the discovery and development of better treatments…

Metabolomics in Dravet syndrome

Primary Objectives: 1. To assess the metabolic profile of patients with Dravet syndrome and identify metabolic variations that contribute to the pathophysiology of seizures and developmental delaySecondary Objectives:2. To assess the association…

A multicenter, international, randomized, active comparator-controlled, double-blind, doubledummy, parallel-group, 2-arm, Phase 3 study to compare the efficacy and safety of the oral FXIa inhibitor Asundexian (BAY 2433334) with apixaban for the prevention of stroke or systemic embolism in male and female participants aged 18 years and older with atrial fibrillation at risk for stroke

This study has been transitioned to CTIS with ID 2023-503794-38-00 check the CTIS register for the current data. - To demonstrate that asundexian is superior (at least non-inferior) when compared with apixaban for prevention of stroke and systemic…

A Phase 3, Prospective, Randomized, Open-label, Adaptive Group Sequential, Multicenter Trial with Blinded Endpoint Assessment to Evaluate the Efficacy and Safety of TAK-330 for the Reversal of Direct Oral Factor Xa Inhibitor-induced Anticoagulation in Patients Requiring Urgent Surgery/Invasive Procedure

This study has been transitioned to CTIS with ID 2022-503012-16-00 check the CTIS register for the current data. To evaluate intraoperative efficacy of PROTHROMPLEX TOTAL in comparison with standard of care (SOC) 4F-PCC, for reversal of…

Diaphragm PARAlysis : Surgery Or mechanicaL ventilation?

The following questions will be addressed in the PARASOL study• Is the proposed study design feasible?,We will set up the study as a randomized pilot study to evaluate if patients are willing and able to participate in a randomized trial, i.e. are…

ProMIO 2.0; a powerful lifestyle intervention for older adults from ethnic minorities

Primary Objective: - To investigate the effectiveness of the ProMIO lifestyle intervention (targeting protein intake and exercise behavior) on physical functioning in older adults from ethnic minorities (Turkish, Moroccan and Surinamese). Secondary…