729 results
Main objective: To determine the impact of FDG-PET/CT on decreasing the fraction of patients with cytologically indeterminate thyroid nodules undergoing unbeneficial patient management.
To compare HM to ultrasound guided electric vacuum aspiration (EVA) for removal of placental remnants with respect to the risk of IUA formation, and in terms of efficiency and complications.
We hypothesize that the long-term efficacy of POEM is comparable to the efficacy of laparoscopic Heller myotomy in treatment of patients with symptomatic idiopathic achalasia. The assumption is thus that POEM is non-inferior to laparoscopic Heller…
The primary efficacy objective for this study is as follows:* To evaluate the efficacy of etrolizumab (105 mg subcutaneous [SC] every 4 weeks [Q4W]) compared with infliximab in achieving both clinical response at Week (W) 10, and clinical remission…
This study has been transitioned to CTIS with ID 2024-512657-24-00 check the CTIS register for the current data. Stratum 1:To show that a non total body irradiation (TBI) containing conditioning (Flu/Thio/ivBu) results in a non inferior survival as…
The main objective is to compare growth and body composition of late preterm infants at 6 months corrected age, fed either an isocaloric, protein- and mineral-enriched ('postdischarge') formula (PDF) or standard term formula (TF) between…
The primary objective of this Randomised Controlled Trial (RCT) is to evaluate the efficacy of DRG stimulation with the Axium® SCS system as compared to CMM in terms of pain relief. Efficacy will be assessed by comparing the percentage of subjects…
The primary objective of the study is to assess if treatment with veliparib plus carboplatin and paclitaxel results in improved survival compared to Investigator's choice of standard chemotherapy in Lung Subtype Panel (LSP) positive subjects…
The 4D-EEG study aims to elucidate the underlying mechanisms of upper limb functional recovery using high density portableEEG (electroencephalography) methodology as well as clinical measures of motor function. The following questions are addressed:…
The main aim of this study is to examine predictors of (changes in) employment status and work absenteeism in relapsing-remitting MS patients and subjects without a chronic disease over a period of three years
In women with early, mild PPH (blood loss 500-750ml) we would like to establish whether restrictive resuscitation strategy reduces the progression to severe PPH (blood loss > 1000 ml) compared to care as usual
The main objective of this study was to assess whether the proven effective standard treatment for PTSD knowing Imaginary Exposure in PTSD patients with comorbid many symptoms ( such as depression and middelenafhankeliijkheid ) , which allows…
Primary ObjectiveThe primary objective is to evaluate the effectiveness of adding Epanova to statin therapy (with or without ezetimibe) for lowering MACE (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, emergent/elective…
This protocol is designed to determine the safety, tolerability, and efficacy of SGI-110 in combination with irinotecan in previously treated patients with metastatic colorectal cancer who progressed on irinotecan.
The primary efficacy objective is to assess the incidence of symptomatic recurrent venous thromboembolism.The secondary efficacy objective is to assess the incidence of symptomatic recurrent venous thromboembolism and asymptomatic deterioration on…
The main objective of this study is whether EMDR is an appropriate treatment for women with PTSD after a previous birth. The resulting hypotheses are that at the two follow-up meaurements, in relation to the pretreatment-measurement 1) WITHIN the…
To evaluate the effect of pneumodilatation (PD) on prolonged dysphagia after Toupet or Nissen fundoplication compared to sham dilatation.
Primary objective is to investigate whether secondary deterioration after acute stroke is associated with CSD, infraslow activity, or epileptiform activity. Secondary objectives are (1) to assess the feasibility of continuous full-band EEG to…
More knowledge on immunity to VZV in these patient groups is necessary to be able to design preventive strategies to VZV infections in the future. To reach these goals, the proposed study is divided into two parts. The first part aims to determine…
Quizartinib selectively inhibits survival pathways that block apoptosis by inhibiting FLT3. Quizartinib inhibits proliferation of FLT3-dependent cell lines, and is effective in human leukemia tumor xenograft models of AML. Data from the Phase 1 and…