63 results
1. To investigate non-invasive 4D flow CMR for the assessment of aortic arch stenosis and compare and correlate this to conventional imaging modalities and to three-dimensional rotational angiography (3DRA) with computational fluid dynamics (CFD). 2…
Primary objectives: to investigate functional and histopathological changes of the right ventricle before and after PVR and PPVI. To investigate if non-invasive assessment of RV-remodeling using CMR T1 mapping and T1rho mapping is possible and to…
Cross-sectional study: To detect the normal range of amplitudes and segment intervals of the fECG. Case-cohort study: To compare the fECG between healthy fetuses and fetuses with various forms of severe CHD. To determine the diagnostic value of fECG…
To assess the accuracy and cost-effectiveness of PO screening for CCHD in the Dutch perinatal care system.
The primary objective is to investigate the determinants of aortic root deformation occurring >= 3 months after successful ASO implantation in adult patients with an atrial septal defect.
The aim of this study is to investigate the relationship between atrial septal defects and airway responsiveness before and after percutaneous closure.
The aim of this study is to identify genetic defects underlying CHD and aortic aneurysms. This will provide insight in the aetiology and heredity of these diseases.
This study is aimed at determining pharmacokinetics and pharmacodynamics of medications routinely used at the Erasmus Medical Centre in pediatric cardiac surgery during and after cardiopulmonary bypass. The goal is to be able to formulate evidence…
First objective: To assess late neonatal neurological outcome in infants with duct dependent CHD and to gain more insight into the timing of brain damage. We will determine whether the quality of GMs at an age of seven days and three months is…
To investigate whether it is feasible to perform a large national implementation study in which community based midwives in the Netherlands use a pulse oximeter for screening newborns for CHD.
Primary Objective:• Intracardiac blood total flow and maximum flow velocity measured by 4D MR, and compared with 2D MR.Secondary Objective(s):• Intracardiac pressures as assessed by 4D MR , compared with 2D MR, invasive catheterization and…
The primary objective of this study will be to investigate reproducibility of ROI-TDI for fetal cardial performance in a group of normal pregnancies, and compare this new proposed parameter with the Myocardial Performance Index. The data will be…
1. To obtain early diagnostic and prognostic markers for preterm premature rupture of membranes and premature labour, based on ultrasound examinations of mother, placenta and fetus and markers present in blood and urine of mother at 11-14 weeks and…
Our primary objective is to identify the patients with congenital heart defects in whom CHD7 mutation detection is needed. Secondly we want to identify the co-existing medical problems in children with a congenital heart defect due to a CHD7…
primary objective:-to define the optimal glucose intake by quantifying endogenous glucose production and fractional gluconeogenesis in critically ill children.secundary objectives:-determine glucose utilization in relation with exogenous glucose…
The current pilot-study will examine the relation between depressive symptoms and serum levels of pro-inflammatory cytokines in CHD-patients.
The PRELHUDE study investigates the reversal of the ZAHARA3 study; whether subclinical congenital heart disease occurs in women who deliver prematurely for unknown reason. The biosamples taken during and after delivery will be used to determine…
To evaluate the clinical usefulness of the VU-AMS in pediatric cardiology.To validate and improve the measures of stroke volume from the VU-AMS device. VU-AMS stroke volume measures will be compared with stroke volume measured by echocardiography.To…
Fontan circulation: Analysis of its Impact on quality of life and Rate of deterioration (FAIR study)
Primary Objective: - Investigating the rate of the attrition and predictors of the failing Fontan circulation, defined as decrease in functional capacity. Secondary Objective(s): - Investigating predictors of decrease in NYHA class of Fontan…
We will investigate the feasibility of using STIC technology to evaluate the normal fetal cardiac anatomy and morphology in different stages of gestation. Further we aim at making normograms of different intracardiac parameters in relation to…