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Needle based CLE in thoracic lymph nodes, a comparison with pathology.

To identify and define characteristics of healthy lymph nodes and lymph nodes involved in different pulmonal diseases (lungcancer and sarcoidosis)

Non-invasive MRI spectroscopy at 7 Tesla in lymphoma

The primary objective of this project is to investigate whether 7T MRI spectroscopy biomarkers lactate and phospholipids can differentiate between aggressive and indolent lymphoma non-invasively. The secondary objective of this study is to assess…

A Phase I Study to Evaluate the Safety and Tolerability of the Histone Deacetylase Inhibitor, CHR-2845, in Patients with Advanced or Treatment Refractory Haematological Diseases or Lymphoid Malignancies

Primary objective:* To determine the safety, tolerability, dose-limiting toxicities (DLT), maximum acceptable dose (MAD) and maximum tolerated dose (MTD) of CHR-2845 when administered orally to patients with advanced or treatment refractory…

Single centre study comparing results of pathologic analysis of EUS-FNA with EUS-TCB in patients with enlarged mediastinal lymph nodes.

Primary Objective: The primary objective is to investigate whether EUS-TCB had an added value on EUS-FNA alone. Secondary Objective(s): The secondary objective is to study whether EUS-TCB does not have a higher complication rate than EUS-FNA alone.

Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) at different magnetic field strengths in healthy volunteers

The aims of this study are 1) to examine which magnetic field strength (1.0, 1.5, or 3.0 T) 2) in combination with which fat-suppression technique (STIR or SPIR/SPAIR) results in the best DWIBS images, 3) to detemine which respiration technique…

Whole-body MR imaging for staging malignant lymphomas in children

The aim of this study is to examine if WB-MRI can replace CT in staging of patients with a malignant lymphoma.

Whole-body MR imaging for staging malignant lymphomas in adults

The aim of this study is to examine if WB-MRI can replace CT in staging of patients with a malignant lymphoma.

89Zr-rituximab PET/CT for detection of central nervous system lymphoma

The objective of the study is to confirm that PCNSL is positive on 89Zr-rituximab PET imaging.

A Phase 1, Open-Label, Multicentre, Non-Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of AZD4573, a Potent and Selective CDK9 Inhibitor, in Subjects with Relapsed or Refractory Haematological Malignancies

Primary Objective:Assess the safety and explore the biologically effective dose (BED) and/or the maximum tolerated dose (MTD) and/or the recommended Phase II dose (RP2D) of AZD4573 in patients with relapsed or refractory haematological…

Enhancement of immune response by combining immune checkpoint blockade and radiation in patients with recurrent / refractory malignant lymphoma (re-directing the immune system).

This translational study focusses on the altered / improved immune response triggered by the addition of radiation to immune checkpoint blockade therapy. The study is investigative in nature.Main study parameters/endpoints:a) Alteration / increase…

An Open-label, Randomized, Crossover, Single Ascending Dose Pharmacokinetic Study of Continuous Subcutaneous Infusion of Lenalidomide Compared with Revlimid® Oral Capsules in Healthy Adult Male Subjects

The purpose of this study is to investigate how quickly and to what extend lenalidomide is absorbed and eliminated from the body (this is called pharmacokinetics). In this study the pharmacokinetics will be compared when lenalidomide is administered…

A Phase 2b , Open-Label Study of Selinexor (KPT-330) in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

Primary Objective:To evaluate the efficacy of selinexor 60 mg in comparison to a minimally effective lower threshold level of ORR of 15% in patients with R/R DLBCL Secondary Objectives:* To determine DOR* To determine the disease control rate (DCR…