275 results
Primary objective: To evaluate the in vivo biodistribution (measured in SUV) and quantitative radioactivity in organs of 89Zr-AMG211 in patients with relapse/refractory gastrointestinal adenocarcinoma as assessed by PET/CT. Secondary objectives: I)…
The aim of this present diagnostic study is to determine the accuracy by which we can detect residual disease after neoadjuvant chemoradiotherapy.
To evaluate the detection ctDNA in patients with PC of colorectal origin undergoing cytoreductive surgery and HIPEC at time of diagnosis in a feasibility trial This study is considered feasible:1. If in at least 70% of the patients ctDNA status…
Currently, only few publications exist which describe MRI for esophageal cancer. Therefore, the objective of the study is to develop a MRI protocol for imaging of this organ. The research will particularly be focussed on functional MRI. Those scans…
The objective of the current proposal is to assess, in a phase 1/2 study, the safety and efficacy of this synthetic vaccine SLP-HPV-01® in HIV+ men with CD4 counts > 350 x 10E6/l and intra-anal high-grade, HPV16 positive AIN, who failed on…
The primary aim of the study is to assess whether DWI, DCE-MRI, T2*, and 18F-HX4-PET/CT predict overall survival in patients with pancreatic cancer treated with surgery and adjuvant chemotherapy or with neoadjuvant radiochemotherapy, surgery and…
Part 1 1. Determine if accumulation of the fluorescent tracer bevacizumab-800CW can be detected for identification of pancreatic cancer tissue during surgery.2. Identify two doses of conjugate that provide the best visualization of tumor tissue…
To quantify motion based variation of the target volume of the primary tumor over the course of chemoradiotherapy in esophageal cancer patient, and to use this information to calculate appropriate PTV (planning target volume) margins according to…
The primary objective is to describe the functional outcome of patients that choose for organ saving treatment.
To assess the safety and feasibility of curative esophagectomy combined with three field lymphadenectomy after chemo-radiation in Western patients with resectable thoracic esophageal carcinoma and cervical lymph node metastases in level III and/ or…
The primary aim is to study colon motility following rectal resection with the construction of a deviating ileostomy in patients that received an enema as bowel preparation. We hypothesise that CTT is halted or decreased, similar as in patients that…
1. Evaluate the feasibility of ESS for detection of field cancerization in BE patients. 2. Investigate the biological background of field cancerization by studying: a) (ultra)structural changes in the tissue and b) genetic abnormalities and clonal…
1. To determine the optimal acquisition technique for USPIO enhanced MRI (without contrast injection), DCE (without contrast injection) and DWI and T2* MRI of esophageal cancer in terms of signal-to-noise ratio, time resolution and spatial…
To investigate feasibility, safety and toxicity as well as immune-response of an allogeneic tumor cell lysate (PheraLys) loaded onto autologous dendritic cells (MesoPher) in resected pancreatic cancer patients who received adjuvant standard of care…
The primary objective of this study is to evaluate the efficacy of INCB054828 in subjects with advanced/metastatic or surgically unresectable cholangiocarcinoma with fibroblast growth factor receptor (FGFR) 2 translocation who have failed at least 1…
This is a prospective phase II non-randomized single-center study in patients with LAPC. Patients are first treated with up to 8 cycles of FOLFIRINOX, followed by stereotactic radiotherapy for a total dose of 40 Gy in 5 fractions. Due to the known…
The aim of this study is to compare the image quality, diagnostic confidence and patient discomfort when using either positive (50 ml Télébrix Gastro + 950 ml water ) or negative 1000 ml water only in outpatients undergoing a contrast-enhanced…
The primary objective of this study is to investigate the capability of diffusion weighted magnetic resonance imaging (DWI) to assess tumor resectability after FOLFIRINOX, compared to standard CT scan.
Phase I study to investigate safety of the combination indomethacin and two platinum-based chemotherapy regimens in patients with advanced cancers.
Predictive factors are needed to discriminate chemoradiotherapy responders from non-responders and to individualize the treatment regime. Various cytokines play a role in processes affecting tumour growth and metastasis. Furthermore, cytokines might…