160 results
The primary objective of this study is to obtain clinical proof of principle that the addition of a PgP/BCRP inhibitor increases CNS concentrations of tyrosine kinase inhibitors by inhibition of drug efflux transporter function in the blood brain…
Primary objective: to explore 18F-FDHT PET/CT as a predictor of response in patients with metastasized CRPC to be treated with enzalutamide. Secondary objective: to explore 18F-FDHT PET/CT as a predictor of clinical survival endpoints in patients…
To investigate lesion detection in patients with liver metastases of colorectal cancer with [18F] FLT-PET compared to CT at baseline (= gold standard). This investigation will be done based on a qualitative assessment of the scans ([18F] FLT-PET and…
Main objective of this study is to determine if the [18F]FB-IL2 PET is able to detect a treatment-induced immune response in tumor lesions of patients with metastatic melanoma and if the tumor uptake of the tracer correlates with the number of IL2…
Primary objectives:- To determine the maximum tolerated dose (MTD) of sunitinib when administered once a week or once every two weeks.- To assess the safety and tolerability of sunitinib in a once weekly or once every two weeks dose schedule- To…
Tumor organoids: feasibility to predict sensitivity to treatment in cancer patients (TUMOROID trial)
• Evaluate the potential of tumor organoid therapy response to predict treatment response in the patient • Design a standardized organoid screening test and propose a test threshold that ensures a high negative predictive value• Establish the…
1. To evaluate the feasibility of 18F-FDG PET/CT, or WB MRI or both to determine metastatic tumour load before and after treatment with Enzalutamide in CRPC patients. 2. To evaluate how these 2 imaging modalities perform compared to traditional…
Primary objective is to determine the absolute uptake (Standardized uptake value (SUV)) and kinetics (time-activity curves) of [18F]dabrafenib in normal brain and brain metastasis. Secondary objectives are to analyze heterogeneity in [18F]dabrafenib…
Primary Objective: Prediction of PCI with DWI MRI, using the surgically determined PCI as the reference standard.Secondary Objective(s): - MR Protocol optimisation- Comparison of the diagnostic performance of DWI-MRI in assessing the PCI with the…
To validate nano-MRI on 7 Tesla with pathological findings.
Primary Objective:-Evaluate tumour detection sensitivity and specificity with the following image enhancement modalities:1 *narrow-band imaging*, (NBI)2 *near-infrared indocyanin green imaging*, (ICG)3 *5-aminolevulinic acid fluorescent imaging*, (5…
To prove the clinical feasibility of palliative whole brain radiotherapy without using a thermoplastic mask. Clinical feasibility in this study is defined when more than 70% of the patients can complete the radiation treatment without a mask. We…
To evaluate the safety and toxicity of ACT and low-dose IFN-alpha plus nivolumab according to CTCAE 4.0 criteria. Toxicity grade 3 or less and SAE related to treatment but that do not result in treatment termination are considered acceptable for…
The primary objective of this trial is to evaluate the efficacy of vemurafenib using BestOverall Response Rate (BORR), as assessed by an Independent Review Committee (IRC)using RECIST, v1.1 criteria in the brain of metastatic melanoma patients with…
The primary objective of this study is to evaluate the safety in terms of complication rate of IRE in the treatment of colorectal liver metastasis/es <3,5 cm in patients undergoing surgical resection (metastatectomy, segmental liver resection…
To study the safety, feasibility ,t oxicity , tolerance and respons rate (RECIST-criteria) of the intra-arterial treatment with Doxirubicin -loaded Beads (DEBDOX) in patients with liver dominant metastasized breast cancer.
The primary objective of this study is to evaluate effectiveness of the Philips Sonalleve MR-HIFU device for the palliation of pain in patients with bone metastases.
The aim of the present study is to measure the test-retest reproducibility of DW-MRI in healthy volunteers, in patients with colorectal liver metastases and in patients with malignant lung lesions in a multicenter setting.
Primary Objective: the primary objective of this study is to determine the feasibility of [18F]FDHT PET/CT for in vivo evaluation of bone metastases in prostate cancer. Active locations will be compared with those seen on conventional imaging (bone…
* To stratify cancer patients for participation in clinical trials.