5606 results
Human intestinal biopsies will be used to further develop an in vitro intestinal model. This model will the be used for future research to study the effect of nutreints and drugs on intestinal function. The human biopsies will be compared with…
The primary objective of the study is to determine the gain in effectiveness of TE compared with P when applied to remove excess iron during maintenance therapy of HH patients.
To determine the maximum tolerated dose, dose limiting toxicity and recommended Phase 2 dose of BMS-753493 in subjects with advanced cancer.
Hypotheses1) The use of a combination of probiotic strains results in a significant increase in defecation frequency in pregnant women with constipation.2) The use of a combination of probiotic strains results in less episodes of difficult…
Primary objective:* To determine the safety, tolerability, dose-limiting toxicities (DLT), maximum acceptable dose (MAD) and maximum tolerated dose (MTD) of CHR-2845 when administered orally to patients with advanced or treatment refractory…
The primary objective of this study is to determine the progression-free survival (PFS) rate assessed 12 weeks after the initiation of IMC-A12 monotherapy, administered every 2 weeks to patients with previously-treated, advanced or metastatic soft…
Objective is to show equivalence with respect to the efficacy of sugammadex in subjects with normal or severely impaired renal function, to evaluate the safety of sugammadex in these subject groups and to compare the pharmacokinetic profiles.
The primary objective of the study is to quantitatively determine the pharmacokinetics (distribution, metabolism, and excretion) of [14C]bendamustine and its metabolites in patients with confirmed, relapsed or refractory malignancy (hematologic or…
To compare the success rate and the occurrence of complications of re-crossectomy and (repeated) UGFS for the treatment of recurrence of the SSV for a period of 5 years.
Primary objective:The main objective of this study is to assess the feasibility, tolerability and the maximum tolerated dose (MTD) of oral AT-101 in combination with concurrent cisplatin-based chemotherapy and radiotherapy (RT) in advanced HNSCC, as…
Primary Objective: Improvement in myocardial blood flow and reverse remodelingSecondary Objective(s): Improvement in wall motion abnormalities, left ventricular function and NYHA class
Comparing the metabolic response (oxygenuptake and ventilation) and symptom perception (borgscores for dyspnoea and fatigue) between neuromuscular electrical stimulation with low-frequency and high-frequency.
The primary objective is to avoid cognitive and affective side effects and maintain the beneficial motor effects by selective stimulation of the STN motor part. With the Select Stim project we want to improve the classical operation procedure, in…
The present study is intended to prospectively evaluate the validity of PET/CT with regard to target volume definition by assessing the incidence of locoregional recurrences outside the CTV among patients with esophageal cancer.The hypothesis to be…
The main purpose of this pilot study is to evaluate the safety of the PANDIT system by testing the system in a group of patients, under strict supervision of a diabetes nurse. The main objective is to check whether PANDIT provides correct insulin…
The goal of the current study is to investigate the correlation of IntelliCap generated environmental information (gastrointestinal pH and temperature) with an established nuclear imaging technique. In addition, the functionality of the IntelliCap…
The purpose of this clinical study is to provide confirmation of the clinical safety and performance of the CINCOR* System in patients at risk of developing CIN who are undergoing interventional percutaneous coronary procedures.Further, the data…
The primary objective of this study is to determine the effects of aliskiren, as compared to ramipril, on renal hemodynamics in overweight/obese and hypertensive patients.
Right ventricular function will be assessed by invasive pressure-volume loop analysis using combined pressure-conductance catheters [27,28]. The response of right ventricular function to increased afterload, induced by brief, partial clamping of the…
Primary objective is to assess differences in endogenous hypoxia markers (CA9, PAI-1, VEGF [Rademakers et al. 2008]) and autophagy (LC3b [Rouschop et al. 2010]) before and after short-term pre-surgical treatment with HCQ in breast cancer patients.…