261 results
Primary Objective: Improvement in myocardial blood flow and reverse remodelingSecondary Objective(s): Improvement in wall motion abnormalities, left ventricular function and NYHA class
We aim to investigate which part of the pulmonary vasculature, the obstructed or non-obstructed, is responsible for the pulmonary vasodilator response.
Primary:To investigate the effect of VLCD (very low calorie diet) in obese patients with type 2 DM and cardiovascular complications on cardiac function, pulse wave velocity and myocardial triglyceride contentSecondary:To investigate the effect of…
The primary purposes of this study is to characterize the optimal electrode placement and electrode spacing on the lead*s spiral fixation such that at least one electrode on the spiral will contact the myocardium site in the coronary vein. Secondary…
The primary objective of this study is to asses whether HIF signaling pathways show less activity in patients with preserved ejection fraction compared to patients with systolic dysfunction. Secondary objectives are to assess the relation between…
To determine the performance of CardioFit* for the treatment of Class II-IV Heart Failure patients with preserved left ventricular function
Primary Objective: In 2 study groups, patients with COPD and patients with chronic heart failure:• To investigate whether, in comparison to unaided walking, the increase in 6 minute walking distance (6MWD) using a walking bike is greater than the…
Aim of the Maastricht StudyThe primary objectives of the Maastricht Study are:1. to study the development of obesity, the metabolic syndrome and type 2diabetes in the general population.2. to study the development of cardiovascular disease in the…
The aim of our study is to identify the same 4 circulating analytes identified in the animal models in human subjects. An additional task will be to measure the basal levels and the inter-individual variability.
To study the effects of pulmonary rehabilitation on daily physical activity in patients with COPD and CHF.It seems reasonable to hypothesize that an improved sub-maximal performance capacity following pulmonary rehabilitation and the correct use of…
The aim of the current study is to improve the diagnosis of iron overload in MDS patients. The primary objectives are to evaluate 1. the relationship between red blood cell transfusions and iron overload in liver and heart as investigated by MRI T2…
1. To assess prevalence of SAS in a Dutch chronic heart failure (CHF) population. 2. To assess whether there are group differences between CHF-patients without SAS and CHF-patients with SAS (OSAS and CSAS). 3. To assess the validity of the ApneaLink…
The primary objective is to determine if echocardiography in combination with plasma biomarkers can be used as a potential predictor for pulmonary hypertension. The secondary objectives are assessment of a potential correlation between…
To demonstrate that CNBP can be used for CRT device settings adjustment aimed atoptimization of clinical status of chronic HF patients
The main aim of the present study is to validate a predictive multiparametric algorithm to predict the response to CRT in terms of the amount of decrease in LV end systolic volume (LVESV). The model combines typical left bundle branch block (LBBB)…
The statistical analysis will evaluate the correlation of Baseline NGAL and BNP levels -alone and together - with the clinical outcomes of hart-failure (HF-related adverse clinical outcomesthrough Day 30 and Day 90. The cut-off and estimated…
The main objective of this study is: • To determine the optimal site to position the left ventricular pacing lead for each individual patient with an ischemic Cardiomyopathy (CMP). The site is selected based on the latest mechanical activated site…
To attenuate the clinical severity of right ventricular disease by electrical pacing
The main objective is to investigate mechanical alternans and MTWA in patients with heart failure caused by coronary artery disease to demonstrate a possible correlation between these two phenomena.
The aim of the present study is to investigate whether the relation between QRS vector, interventricular asynchrony and improvement in LV pump function is present in CRT patients. Subsequently, we want to show that the QRS vector can be used as a…