209 results
The primary objective is to assess the feasibility and accuracy of dynamic contrast enhanced MRI in diagnosing UC or CD in children as compared to endoscopy and abdominal ultrasound.The secondary objective is to assess the feasibility of dynamic…
zie K1
To study MRI of the small bowel and colon in determining disease activity in patients with Crohn*s disease.
In this study we will explore the examination with the second generation Pillcam capsule (PCCE 2) in patients with Crohn's disease. Crohn's patients with symptomps that need an endoscopy according to the treating physisian, will be asked…
Primary: • Assess effect of AN-PEP on gluten epitope degradation in the duodenumSecondary: • Assess effect of AN-PEP on gluten epitope degradation in the stomach• Assess effect of meal caloric content on the efficacy of AN-PEP on gluten epitope…
To study whether dynamic MRI can predict treatment response and long term outcome in patients with Crohn*s disease.
To assess the (additional) diagnostic value of faecal calprotectin in children, age 4-18 years, with symptoms suggestive for IBD, in a primary and secondary/tertiary care setting.
The goal of this study is to improve the diagnostic work-up of the small bowel in children suspected of IBD or diagnosed with CD and with suspicion of small bowel disease by comparing enteroscopy as gold standard to ultrasonography, Magnetic…
Monitoring of serum drug levels may help to optimize dosing schedules and decrease the risk of infusion reactions and subsequent treatment failure. In the future we want to routinely measure anti-TNF levels in IBD patients that are treated with…
To determine the correlation between enhancement curves at DCE-MRI with T1-map and DWI and the level of histopathological activity.
1. Determine the presence of lesions in the upper gastrointestinal tract in patients with a primary diagnosis of CD and UC, using endoscopy and histology, before starting medication.2. Asses the prevalence of histological lesions such as focal…
We propose to assess the accuracy of MRI in a multicenter diagnostic accuracy study that will include a consecutive series of patients from the general population with suspected acute appendicitis. Patient acceptance and cost-effectiveness will also…
The aim of the study is to assess the accuracy and feasibility of contrast enhanced ultrasonography (CE-US), in the primary diagnosis and relapse during follow up of small bowel CD, compared to MR enterography. Furthermore we attempt to determine…
The aim of this project is to assess differential responses in immune cells derived from peripheral bloodof IBD patients concerning:Immunological phenotype in CD patients:1. defining the genotype in CD patient cohort2. production of interleukin-8…
This study aims to show that the IFX or AZA are equally effective with the latter being more efficient as maintenance therapy in CD after remission induction with IFX/AZA for at least 6 months as defined by the proportion of patients not needing…
To develop a method to determine Infliximab in feces
Identifying subsets of Crohn's disease (CD) at risk for poor outcomes is a priority in pediatric CD research. Having the ability to predict patients more likely to relapse, to be refractory to therapy or to develop complications may enable…
Primary: Safety and tolerability. Secondary: Effectiveness, quality of life, healthcare resource utilisation, work productivity.
1.1 Safety To evaluate the safety of long-term exposure with AMG 827 in subjects with Crohn*s disease 1.2 Efficacy * To evaluate the efficacy of AMG 827 as measured by the Harvey-Bradshaw Index (HBI) and the Crohn*s Disease Activity Index (CDAI)* To…
The aim of the study is to quantify the accuracy and cost-effectiveness of a diagnostic decision rule for OBD, in patients with persisting lower gastro-intestinal complaints in primary care.