115 results
Primary:To investigate the safety and tolerability of ascending doses of AZD3514 in patients with metastatic castration resistant prostate cancerSecondary: To assess the pharmacokinetics and preliminary anti-tumour activity of ascending doses of…
To obtain data, images and feedback from the initial clinical use of investigational four channel output eCoils designed for Siemens 1.5T and 3.0T scanners compared to the current, commercially available single channel eCoils for these field…
The primary aim of this pilot study is to determine whether CTCs are a reliable predictor of survival in men with CRPC receiving docetaxel-based chemotherapy by using the Veridex CellSearch system and the biomarkers PCA3, TMPRSS2-ERG and biomarker…
The primary objective is to study whether treatment with the mTOR inhibitor Everolimus results in an objectable change in phosphorylation of the selected downstream effectors 4eBP1 and p70S6K in human prostate cancer biopsies. A secondary objective…
To identify pre-malignant lesions within the endometrium as precursor lesions of serous epithelial ovarian carcinoma.
Primary objective:- To evaluate the pharmacokinetics, metabolism, and excretion of MDV3100 in plasma, urine, and feces after a single oral 160 mg (100 µCi) dose of 14C-MDV3100.Secondary objective:- To evaluate safety and tolerability of a single…
Main objective of this study is to test the safety and feasibility of MR-guided focal cryosurgery in newly diagnosed prostate cancer patients and in patients with recurrent prostate cancer after radiotherapy. Secondary objectives are: to determine…
The purpose of our study is to prospectively establish in vivo in patients proof of principle for the RUNMC MR imaging-compatible robotic system designed for image-guided prostatic needle intervention.
The primary objectives of our study are: - Determining the long-term predictive value of a positive HPV test for (pre)malignant cervical disease.- Determining the long-term protective value of a negative HPV test. - Determining the long-term…
To investigate whether advanced-stage prostate cancer patients have circulating prostate (cancer)-specific CD8+ T-lymphocytes
To compare sexual functioning and complaints concerning micturation and defecation in women after abdominal or vaginal trachelectomy for early stage cervical cancer.
To test a near-infrared fluorescence camerasystem in order to detect folate-FITC in tumour tissue in women with ovarian cancer who undergo cytoreductive surgery.
To test an intra-operative fluorescent camera system with a fluorescent optical agent in detection of the sentinel lymph node. This will be compared to the standard method with radiocolloid and patent blue.
to determine the feasibility of real-time detection and quantification of two NIRF optical contrast agents in the detection of sentinel and metastatic LNs in patients with cervical cancer during surgery with a novel NIRF imaging device to provide a…
The potential use of intraoperative, ICG based sentinel node identification, fluorescence imaging of LN*s during lymphadenectomy for prostate cancer
The primary objective is to determine the positive and negative predictive value of an hrHPV test after treatment for the development of recurrent (cervical) disease on the long term.
To evaluate the safety, efficacy and to acquire data on patient experience of minimally invasive, percutaneous, image guided IRE for the ablation of prostate cancer.
In this proposed study, we aim to test not only the safety and biodistribution of [68Ga]Sarabesin 3, but also its potential to visualise prostate cancer. If the peptide proves to be successful, a next study will be initiated to test the potential to…
Primary Objective:To compare the clinical benefit of abiraterone acetate plus prednisone versus placebo plus prednisone in patients with chemotherapy-naïve castration-resistant prostate cancer (CRPC) who are asymptomatic or mildly symptomatic.…
Confirm the interaction between colchicine and the choline pathway as seen with FCH-PET.