3514 results
Primary:To determine the MTD and/or RP2D of BKM120 and MEK162 in combination when administered orally to adult patients with selected advanced solid tumors. Secondary:• To characterize the safety and tolerability of the oral combination of BKM120…
The primary objective of this study is to determine the freedom from local failure in patients alive at 1 year
To evaluate the detection ctDNA in patients with PC of colorectal origin undergoing cytoreductive surgery and HIPEC at time of diagnosis in a feasibility trial This study is considered feasible:1. If in at least 70% of the patients ctDNA status…
Describe the relation between patterns in biomarkers of vascular inflammation, plaque instability and hypercoagulability and the incidence of recurrent ACS
Monitoring and evaluation of the Dutch guideline for treatment of aHUS in children and adults during two years.
Primary objective: Determine for different control algorithms whether the algorithm is effective in providing the patient with the required support and bringing about the desired changes in the walking patternSecondary Objective(s): - Determine…
Primary:To establish a recommended phase II dose of the PARP-inhibitor olaparib in combination with hyperthermia in a) patients with recurrent HNC in previously irradiated area and in b) patients with primary irresectable or local recurrent bladder…
Objective:The aim of our study is to obtain a collection of head and neck squamous cell carcinomas that is well characterized for relevant clinical parameters, including follow-up.
Co-Primary Objectives* To evaluate the immunogenicity of N8-GP in previously treated patients with haemophilia A* To evaluate the clinical efficacy of N8-GP in bleeding prohylaxis (number of bleeds during prophylaxis)Secondary Objectives* To…
To investigate the safety and tolerability of AZD5363 and to define a recommended dose when given orally, either as a continuous or an intermittent schedule, for further clinical evaluation when given to patients with advanced solid malignancies.
The primary objective of this study is to explore user acceptance of the HiM system in the usability study and to examine changes in functional use of the hand during ADL after prolonged use of a wearable robotic device by stroke patients in the…
To assess whether changes in insulin sensitivity through dietary interventions affect postprandial bile acid metabolism and kinetics. Secondary objective: to assess TGR5 and FXR mediated pathways in insulin resistant and insulin sensitive states.
In our previous studies using optical spectroscopy, both ex vivo and in vivo, most promising results were obtained for tissue diagnosis. Moreover, invasive procedures for biopsy or radiofrequency ablation in these tissues are all very common. Thus,…
Distinguishing frontal lobe epilepsy from ADHD in terms of working memory.
The aim of this study is to investigate whether infiltration of the upper eyelid with Citanest is less painful then infiltration of the upper eyelid with Xylocaine. If this hypothesis proves to be correct, then in the future Citanest can be used in…
Zie pagina 39-40 van het protocol MO22923 versie 2, 26 Mei 2011
The first goal of the present study is to elucidate the network topology of the MTL on both large-scale and micro-scale levels with the aim of further understanding epilepsy related changes to the network structure. Additionally we will also use the…
The aim of this prospective study is 1) to evaluate the diagnostic efficacy of DBE in comparison to MRE as surveillance technique of the small-bowel in PJS patients, 2) to analyze patient burden and quality of life with DBE and MRE, and 3) to…
Primary objective1. To determine the effect of food on the pharmacokinetics of buspirone administered as the Lybridos formulationSecondary objective1. To evaluate the safety and tolerability of a single dose of Lybridos under fasted and fed…
To improve diagnostic tools for food/cashew nut allergies with the use of Mediator Release Assays.Genetic component of cashewnut allergy.