49 results
To evaluate the detection ctDNA in patients with PC of colorectal origin undergoing cytoreductive surgery and HIPEC at time of diagnosis in a feasibility trial This study is considered feasible:1. If in at least 70% of the patients ctDNA status…
Monitoring and evaluation of the Dutch guideline for treatment of aHUS in children and adults during two years.
The purpose of this study is to provide insight in to what extent clinically significant systemic absorption of tobramycin occurs (resulting in a serum tobramycin concentration> 1.0 mg / L) in ICU and Medium Care ICU patients who are being…
To document that 8 weeks treatment with ledipasvir-sofosbuvir is effective in chronic HCV genotype 4 patients without cirrhosis.
The aim of the present study is to investigate the added-value of reduction of early signs of spasticity in the upper extremity on improving functional arm-hand skill performance in sub-acute stroke patients with either a severely or moderately…
Aim of this study is to determine the functional outcome after a minimum of 1 year follow-up after fixation of the fractured olecranon with TBW or PF. Subgroup analyses will be done to investigate the assumed advantage of PF compared to TBW in…
This study aims to investigate the process and outcome of the implementation of a coaching intervention in COPD care in the Friesland province.
To determine the resorption of ropivacaïne and serum concentration we need 6 bloodsamples at t=0, t=30 min, t=1 hour, t=2 hour, t=4 hour, t=8 hour. A pharmacokinetic model will be made for each procedure using a software package MW/Pharm © (version…
Primary aim: Frequency of identifying CTCs and their numbers in apheresis product before and after (during) treatment.Secondary aim: Prediction of response to therapy in different stages of NSCLC patient groups with the change in CTC numbers.
The main aim of the current study will be to assess the effect of acute blood flow restriction and blood flow restriction combined with resistance exercise on the muscle protein synthetic rate in healthy young male subjects
The primary objective of this study is to evaluate whether the recovery of the skin barrier after acute perturbation by repetitive application of adhesive tape (*tape stripping*) is accelerated following irradiation with visible light. The secondary…
The objective of this study is to determine frequency, duration and morbidity of (travel-related) health problems and/or exacerbations of underlying illnesses among Dutch travelers of 60 years and older visiting (sub)tropical destinations for a…
Compare the performance of an unobtrusive new medical device with a CE-marked esophageal and/or rectal reference sensor (Covedien Mon-a-Therm, General Purpose Temperature Probe 400TM) for core body temperature in patients undergoing surgery in which…
To determine the prevalence of pruritus and pemphigoid in nursing home patients.To assess the relationship of demographic and medical risk factors with pemphigoid in nursing home patients.To assess the association between pruritus and…
Primary objective:o To evaluate the effect of mild heat acclimation on insulin sensitivity in obese men and womenSecondary objectives:o To evaluate the effect of mild heat acclimation on insulin signalling and heat shock protein expression in human…
The primary objective of the study is to compare gut permeability in metabolic healthier and metabolic unhealthier subjects by performing a MS permeability test. The secondary objectives are to study the correlation between gut permeability assessed…
This study will investigate a comparison group of women treated with a conventional (non-nerve sparing) RHL for cervical cancer (CC) at the Academic Medical Centre (AMC). Together with the data collected of women treated with a nerve sparing radical…
The objective is to assess the safety profile of the hypothermic Airdrive* oxygenated machine perfusion system for graft preservation in kidney transplantation.
The primary objective of this study is to determine the equivalence accuracy of energy expenditure and resting heart rate measurement of newly developed software in reference to currently approved software. Secondary objective is to asses the…
the aim of this prospective cohort study is to investigate the difference in quality of life and satisfaction with cosmetic result in patients with breast cancer undergoing breast conserving therapy surgery versus patients undergoing breast…