13 results
The primary objective of this study is to analyse the microenvironment of the tumour, (sentinel) lymph nodes (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients with vulvar carcinoma. The…
The primary objective of this study is to analyse the microenvironment of the primary tumour and sentinel and non-sentinel lymph node(s) (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients…
To prospectively study the effect of salt restriction on the rise in blood pressure in response to anti-cancer treatment with the VEGF inhibitor sunitinib and regorafenib.
The objective of this pilot study is to assess the feasibility of CMR imaging, and to evaluate the accuracy of left ventricular (LV) functional and volumetric measurements in patients implanted with a CMR compatible CRT-D, with and without…
Primary objective: To accurately assess the direct functional consequences of high versus low phenylalanine levels in adult patients with PKU, using eye-hand coordination testing in tasks of different cognitive complexity. Secondary objective: To…
Objective: In this project we, as a collaborative network of Netherlands academic hospitals from Utrecht, Amsterdam, Rotterdam, Leiden and Groningen, propose to further optimize and validate MG-NIPD at early stages (week 8-10) of pregnancy, in order…
* To determine the relationship between phenotypic and genetic characteristics of GBA-PD patients. Phenotypic characteristics will be obtained by patient dossier review. Genetic characteristics comprise of the GBA1 gene and a panel of SNPs,…
Primary Objectives* To estimate the effect size, at 4 and 8 weeks, of change from baseline in high- resolution computed tomography (HRCT)-based measurements of lobar volumes at functional residual capacity (FRC) and total lung capacity (TLC) in…
This research project is divided into two projects. The first part of the study (Study 1) aims to find an answer to the question whether and to what extent biofeedback is a user-friendly and feasible intervention. In the main study (Study 2), we…
1. The primary objective of the European NAFLD Registry observational study is to assemble a cohort of well-characterised patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and to collect associated clinical information, biological samples and…
The primary objective of this study is to optimize a workflow for identification of circulating melanoma cells in LA using flow cytometry. Secondary objectives include the detection of known mutations in different CMC subsets.
Study Objective(s): To determine if HA dermal filler late occurring (> 4 weeks and < 2 years) nodules are associated with bacterial contamination (independent of filler type) and to characterize the histological response.
Primary objective:To compose multifaceted predictive signatures for PD-1 or anti-PD-L1 antibody effects with relevant components of integrative omics (histology, immunohistochemistry, genomics, transcriptomics, proteomics, radiomics and molecular…