18 results
This protocol describes a framework that will be used to create multiple studies, which are based on the secondary objectives. The outcomes of the studies together will provide more insight in the primary objective. Primary Objective: Investigate…
The goal of this study is to directly compare effectiveness of the Captain Morgan technique to the Allis technique in reduction of posterior dislocation of a THP using procedural sedation and analgesia (PSA) in the ER.
The aim of the proposed study is to define optimal treatment for the Lisfranc fracture dislocation, either primary arthrodesis or open reduction and internal fixation, in regard to quality of life, complications, functional outcomes and cost…
This study has been transitioned to CTIS with ID 2024-512968-57-00 check the CTIS register for the current data. The primary objective of the study is to assess the safety and feasibility of autologous salivary gland stem cell transplantation of the…
To evaluate whether Telisotuzumab Vedotin improves response rate and survival in participants who are c-Met+ with NSCLC. For the additional monotherapy cohort :Primary objective is to evaluate the safety and tolerability of telisotuzumab vedotin…
The objective of this trial is to evaluate safety and tolerability of an experimental drug, EO2401, in combination with another immunological treatment, nivolumab, in patients with advanced or metastatic ACC and progressive MPP.
The goals of this study are to evaluate the union rate, patient satisfaction and functional results of the Anser Clavicle Pin in a larger cohort then approved in the study, Anser; A novel intramedullary device for fixation of midshaft clavicle…
This study has been transitioned to CTIS with ID 2024-512860-75-00 check the CTIS register for the current data. The aim of this feasibility study is to validate pre-treatment [89Zr]-bevacizumab PET/CT as an imaging biomarker for prediction of…
The primary study objective is long-term safety of RGX-501 and secondarily evaluation of the long-term effects of RGX-501 on LDL-C and other lipid parameters.
The potential use of 99mTechnetium (99mTc)-based PSMA-radioguided surgery (99mTc-PSMA-RGS) for salvage lymphadenectomy for PC.
The aim of this study is to evaluate the feasibility and safety of new esophageal preserving treatment algorithm for patients with high-risk T1a or T1b EAC consisting of radical ER of the tumor, followed by a SNNS procedure with selective…
To determine the effect of salt (NaCl) supplementation on (1) physiological parameters (such as serum potassium) and on (2) clinical signs and symptoms and quality of life.
This study has been transitioned to CTIS with ID 2024-514797-45-00 check the CTIS register for the current data. PRIMARY OBJECTIVE: - To assess the (long-term) safety and tolerability profile of RO7248824.SECONDARY OBJECTIVE: - To investigate the…
The primary objective is to assess the role of obstructive sleep apnea related pathophysiological mechanisms in the initiation of atrial fibrillation by a multi-parametric strategy that combines the estimated parameters. The main hypothesis is that…
Safety and performance of Invicta ventricular DF4 leads with active fixation.
Primary(Part I and Part II):- To determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) in the QW and/or Q3W regimens of RO7122290 in combination with cibisatamab after pretreatment with obinutuzumab- To characterize the…
To assess whether an adequate response to pneumococcal antigen, as a marker of overall humoral immune system reactivity, predicts sustained TFR. An adequate response to pneumococcal antigen will be defined as achieving anti-pneumococcal IgG levels…
The goal of this research proposal is to identify biological mechanisms and patterns underlying COPD subgroups based on Western clinical variables, TCM symptom patterns and metabolic data.The secondary objectives can be summarized as collecting…