92 results
To compare the objective response rate between patients with metastatic non-small cell lung cancer characterized by PDL-1 TPS<50% and low cTML (<300 nonsynonymous mutations) and either actionable mutation, inactivating STK11 or KEAP1…
To investigate the fluctuation patterns of different pulmonary parameters in patients with severe asthma, before and after starting a treatment with biologics, using daily measurements with the Respicorder device.
Primary Objective: Is the intervention model feasible and acceptable for clients, parents/caregivers, peers and therapists?Secondary Objective(s): 1) Establishing first evidence of efficacy of peer-mentored CBT in reducing anxiety in adolescents…
The purposes of this study are to uncover- Which clinical and neuroradiological measures can be used to predict the (neuropsychological) outcome and progression of symptoms in children with CMS?We hope that the results will contribute to an overall…
Primary Objective:1. Turnover rate of antigen-specific cells (group I)2. Turnover rate of functional T-cell subsets (group II)Secondary Objective(s):• Determining absolute numbers of antigen (poliovirus, measles, Hepatitis A and Hepatitis B)…
In this prospective interventional feasibility study, we would like to assess the feasibility of a home DC-ECV in the treatment of recurrent symptomatic AF performed by APP in 25 patients.
The current study describes the Rotterdam Cohort (i.e., a sub-project) of the larger Growing Up Together in Society Project, which has the aim to examine combined social contextual, biological, and behavioral mechanisms that drive the transitions…
The objective of the study is to evaluate the benefit of the eCoach in the general practitioner*s office within cardiovascular risk management. Specifically, the eCoach evaluates the effect on individual risk factors and the risk on developing…
The aim of this study is to evaluate the AUC, disease status, presence of ADAbs and treatment burden when switching from IV to SC IFX maintenance treatment in a real-world cohort of IBD patients on IFX monotherapy and combination therapy.
This study has been transitioned to CTIS with ID 2024-517793-25-00 check the CTIS register for the current data. The primary objective of this study is to investigate the local tolerability of isoniazid inhalation by wet nebulization at ascending…
We aim to confirm that Maastro endoluminal HDR contact brachytherapy boosting is feasible and may increase the chance of functional organ sparing of the rectum in patients with rectal cancer.
Primary Objectives• To evaluate prognostic factors of disease progression in subjects with Stargardt disease secondary to mutation in the ABCA4 gene • To further characterize the STGD1 patient population for future interventional clinical studies
The primary objective of the current pilot study will be to assess the feasibility of participant selection methods to identify individuals with cam morphology free of hip OA.Secondary objectives includea) the evaluation of the willingness of…
The objectives of EUROASPIRE VI survey of CVD prevention and diabetes are:1. To determine in patients with established CHD (CHD = acute myocardial infarction (AMI) and acute ischaemia (unstable angina) and patients following revascularisation by a…
The aim is to reduce SSI in PWT2D by implementing a proactive basal-bolus insulin regimen, compared to a widely used reactive sliding scale regimen. It is hypothesised that a proactive basal-bolus insulin regimen targeting glucose levels of 3.9-10…
To evaluate the consistency and diagnostic accuracy of risk profiles using genetic markers across three different sampling modalities: biopsy, brush sampling, and TOS.
The main objective of the study is to optimize the use and user-friendliness of the voice analysis program, which could potentially help with the early detection of acute deterioration in heart failure. Hopefully, we can develop a technique that…
To study the effect of oral/enteral fructose on enterocyte function and on the the gut microbiome and intestinal absorption capacity in patients with short bowel syndrome who are dependent on parenteral nutrition (PN) and/or intravenous (iv) fluids.
To characterize the natural history of exocrine pancreatic function as measured by FE-1 in infants with CF <12 months of age
Primary objective:- Determine the number of unruptured IAs in smoking women aged 50-60 years in the Dutch population in a cohort of 55 participants. Secondary objectives:- Evaluate the possible changes in quality of life associated with a screening…