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Prognostic Factors in treatment of Functional Childhood Constipation. A multicenter observational cohort study in the Netherlands. (The PROFUNCO Study)

This study had two objectives:1. which factors determine outcome of treatment of children with functional childhood constipation referred to the outpatient clinic of multidisciplinary treatment clinics in the Netherlands;2. which factors can be…

A Phase 3, Multicenter, Open-Label Extension Trial of Oral RPC1063 as Therapy for Moderate to Severe Ulcerative Colitis

To evaluate the long-term safety and efficacy of RPC1063 for the treatment of all patients with moderate to severe UCTo evaluate the long-term efficacy of RPC1063 for the treatment of adult patients with moderate to severe UC.

Adaptive phase II randomized non-comparative trial of nivolumab after induction treatment in triple-negative breast cancer (TNBC) patients: TONIC-trial

This study has been transitioned to CTIS with ID 2025-520487-18-00 check the CTIS register for the current data. To determine the activity of nivolumab after four different immune response induction treatments in TNBC patients with metastatic…