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Visualizing beta cells in morbid obese patients with T2D before and after bariatric surgery

The main objective is to examine the change in 68Ga-exendin tracer accumulation in the pancreas (i.e. beta cell mass) after RYGB by quantitative analysis of PET images before and one year after RYGB in morbid obese patients with type 2 diabetes.

A phase 3 multicenter, long-term extension study to evaluate the long-term safety and efficacy of Upadacitinib (ABT-494) in subjects with ulcerative colitis (UC).

This study has been transitioned to CTIS with ID 2023-505699-31-00 check the CTIS register for the current data. To evaluate the Long-Term Safety and Efficacy of upadacitinib.

Complex fractionated atrial electrocardiograms (CFAEs) guided ablation versus pulmonary vein isolation guided ablation in persistent atrial fibrillation, a multicenter randomized trial

to compare the efficacy and safety of complex fractionated atrial electrocardiograms (CFAEs) guided ablation to pulmonary vein isolation based ablation in patients with persistent atrial fibrillation (AF).

Defining the BURden after surgical ablation therapY for the treatment of Atrial Fibrillation

The primary objective of the study is:- to evaluate the burden of AF and quality of life rhythm after thoracoscopic ablation surgery and after port-access concomitant left atrial MAZE surgery by continuous rhythm monitoring (Medtronic Reveal Linq…

A phase II trial in patients with myelofibrosis (primary, post-ET or post PV-MF) treated with the selective JAK2 inhibitor Pacritinib before reduced-intensity conditioning allogeneic stem cell transplantation

Improve allo-SCT transplant outcome using a uniform conditioning regimen and pacritinib pretreatment by means of the proportion of patients with a failure within 6 months post-transplant. Events that are considered a failure are: primary graft…