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Long Term Cardiovascular Disease Event Risk for Patients undergoing Non-Cardiac Surgery. A pilot study.

To determine changes (i.e. pre- vs. postoperative) in 10-year cardiovascular disease (CVD) event risk according to contemporary widely applicable risk models in patients with CVD risk factors who have undergone intermediate-to-high-risk non-cardiac…

A feasibility study for an e-health blended personalised lifestyle intervention to change lifestyle behaviour and reverse the risk for type 2 diabetes in people with prediabetes.

The primary objective is to execute a feasibility study of the ELFI Health lifestyle intervention for three months in people with prediabetes in primary care (based on HbA1c). The secondary objectives are assessing the impact of the ELFI health…

An investigator-initiated prospective, longitudinal, single center, observational study to investigate biomarkers of TDP-43 and oxidized lipid metabolism in Amyotrophic Lateral Sclerosis (ALS).

Primary Objective: To characterise longitudinal changes in biomarkers of TDP-43 pathology and oxidized lipid metabolism in ALS patients. Secondary Objective: To characterize the relationship of longitudinal changes in these biomarkers to changes in…

Post-market Clinical Follow-up Study to Provide Safety, Performance and Clinical Benefits Data of the Vanguard PS Open Box Porous Femoral (Implants and Instrumentation) - A Consecutive Series Study

The objective of this retrospective consecutive series PMCF study is to collect long-term data confirming safety, performance and clinical benefits of the Vanguard PS Open Box Porous Femoral (implants and instrumentation) when used for total knee…

Quantitative Margin Assessment using high-resolution Positron Emission Tomography - Computed Tomography

Primary objective:To investigate the feasibility of a novel high-resolution 18F-FDG PET-CT of surgical specimens of OSCC, STS and OS and compare the results to the gold standard of histopathology. Secondary Objectives:To assess the diagnostic…

The effectiveness of a diet with beef as key protein component versus a plant-based diet to support integrated muscle protein synthesis rates in healthy older individuals

To compare the effectiveness of a diet with beef as key protein source versus an isocaloric and isonitrogenous plant-based diet to stimulate integrated muscle protein synthesis rates over a 10 day period, in healthy older individuals, with and…

Personalized follow-up in HPV-related oropharyngeal cancer patients using liquid biopsies

The aim of the proposed study is to investigate the accuracy of a liquid biopsy test using ddPCR for HPV DNA in a standardized follow-up setting for the detection of residual disease and/or (early) tumor recurrence in HPV-related oropharyngeal…

Retrospective evaluation of surgically treated unstable type C ankle fractures: long term functional and radiological outcomes.

To evaluate the long term functional and radiological effects of surgical treatment of Weber type C (AO 44-C1/2/3) fibular fractures

Cerebrospinal fluid concentrations of polyols following traumatic brain injury

Primary objective:i. Investigate cerebrospinal fluid (CSF) polyol concentrations in patients following traumatic brain injurySecondary objectives:i. Investigate the association between plasma glucose, CSF glucose and CSF polyols following traumatic…

Artificial Intelligence-assisted Diagnostics in Angina with No Obstructive Coronary Artery Disease

1.1 Primary Objectives1. To document the prevalence of ischemic intracoronary electrocardiogram changes in ANOCA patients with equivocal acetylcholine provocation test results.2. To document the diagnostic efficacy of the 12-lead Holter ECG to…

Feasibility and to explore the effect of biofeedback gait training on the GRAIL in clubfoot patients, over 4 years of age, with a mild relapse

Is biofeedback gait training on the Gait Real Time Interactive Lab (GRAIL) feasible in children with mild recurrent clubfoot over 4 years of age? And to explore the effect in achieving clinically relevant immediate and short-term improvements in…

An explorative study to assess novel measurement methods for evaluating speech and swallowing function in healthy volunteers and patients with tongue carcinoma (stage I-II)

The first part of the study aims to depict speech and swallowing function with 3D-dMRI in healthy volunteers to establish a set protocol for use in patients. The second part of the study will investigate if anatomical and functional differences in…