40 results
Pharmacokinetic and pharmacodynamic properties of amlodipine oral liquid in the pediatric population
The primary objective of this study is to characterize the pharmacokinetic properties of amlodipine using the newly developed amlodipine oral solution 0.5 mg/ml in patients with chronic kidney diseases (CKD) and/or hypertension aged 6 months to…
The OneShotTM System procedure is designed to provide the anatomical and physiologic benefits of catheter-based RDN at lesser risk to the subject, due to a reduction of complexity of the procedure and design improvements intended to enhance…
To evaluate the safety and performance of the BackBeat Moderato system.
To test the efficacy of renal sympathetic denervation therapy with a special focus on preservation of renal allograft function.
The primary objective is to evaluate the safety and efficacy of the PulseCath iVAC2L in highriskPCI patients who require left ventricular assistance. Safety will be assessed by theincidence of Cerebrovascular Accidents (CVA*s), thrombo-embolic…
The purpose of this Clinical investigation is to further evaluate the safety and performance of the EnligHTN* Renal Denervation System in the treatment of patients with uncontrolled hypertension.
Renal sympathetic denervation is currently introduced in the Erasmus Medical Center. Th objective of the current study is to 1) study the effectiveness and safety of renal sympathetic denervation in patient with treatment resistent hypertension. 2)…
to investigate in a descriptive way the dose-dependent effect of Olmesartan Medoxomil 20mg, 40mg en 80mg on arterial stiffness.
Aim of the study is to study a new therapeutic option for the treatment of hypertension
The aim of this study is to assess and compare the pharmacokinetic parameters of the newly developed amlodipine besilate oral liquid 0,5 mg/ml with commercial Norvasc 5 mg tablets. The secondary objective is to assess the taste of the oral liquid.
To assess the feasibility and effects on blood pressure and cardiac and renal function of RSD after renal transplantation.
Primary:To assess after administration of a single oral dose of 75 mg S 38844 containing 55 *Ci (2.035 MBq) of [14C]-S 38844:* The excretion balance of total radioactivity;* The pharmacokinetics of total radioactivity in blood and plasma;* The…
The purpose of this clinical investigation is to verify the efficacy and safety of the CVRx Neo Baroreflex Activation Therapy System in subjects who qualify for the implantation for a Baroreflex Activation Therapy System.
To determine the effect of bevacizumab on vascular tone in humans by using plethysmography.
The primary objective of the study is to investigate the effect of sunitinib on endothelial function, insulin sensitivity, renal function and renal blood flow.
The Primary objective is to assess the long-term (6 month and 12 month) safety of the combination of aliskiren 300 mg/ valsartan 320 mg in patients with essential hypertension (msDBP > 90 mmHg and < 110 mmHg.
The primary aim for this study therefore is:1. To study the effects of an 8-week exercise training on RNA expression profiles in adipose tissue and skeletal muscle in obese individualsSecondarily we also aim:2. To relate changes in RNA expression…
Main objectives are twofold: 1) To investigate the feasibility of RNS in patients with therapy resistant hypertension, which is assessing the functional distribution of renal nerves using 3D imaging and differential pacing modalities.2) To…
To provide UT-15C for eligible subjects who participated in study protocol TDE-PH-310
To assess the long-term BP lowering effect of renal denervation using a dedicated circumferential ultrasound balloon catheter in patients with resistant hypertension.