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Preoperative Accelerated Partial Breast Irradiation in patients with locally recurrent or second primary breast cancer

The PAPBI-3 trial is a phase I/II interventional trial assessing the toxicity and feasibility of repeat breast conserving therapy with preoperative partial breast irradiation in female patients aged 51 years or older with ipsilateral recurrent or…

Improving radical resection rates in patients with breast cancer by intraoperative imaging using bevacizumab-IRDye800CW - the MARGIN-2 study

Primary objectives -To determine whether real-time tumor visualization using targeted fluorescent imaging during breast conserving therapy in breast cancer patients can be achieved intraoperatively and results in adequate assessment of the tumor…

Interventional ductoscopy in patients with (premalignant) intraductal lesion(s)

The primary objective is to assess the feasibility of intraductal biopsy and intraductal laser ablation in patients with intraductal lesions. Secondary objectives are: treatment success of interventional ductoscopy (biopsy and laser ablation) in…

Breast reconstruction and neoadjuvant radiotherapy, a changing algorithm.

The purpose of the pilot study is to assess acute post-surgical complications following mastectomy and immediate breast reconstruction after NART. We hypothesize that NART will avoid the negative effects of PMRT on the capsule of an implant, or on…

Surgical trauma and postoperative immune suppression in breast-conserving surgery versus mastectomy: a pilot study

Comparing the release of DAMPs and subsequent immune suppression after breast-conserving surgery versus mastectomy.

Geometric accuracy of accelerated partial breast irradiation on the Cyberknife using standard surgical clips as a fiducial marker

The primary objective is to prospectively quantify the geometric uncertainty of CK-APBI and to propose a validated PTV margin.Secondary objectives are: - To evaluate the success rate of using surgical clips as fiducial markers- To evaluate the…

Magnetic marker localisation for non-palpable breast cancer.

The primary objective of this study is to determine the competence of a magnetic marker as a technique to localise non-palpable breast cancer, measured through retrieval rate using only the magnetic probe. The secondary objectives of this study are…

The treatment of breast cancer with thermal ablation: a pilot study

The primary objective is to investigate if thermal ablation of breast tumors less than 2cm with < 25% DCIS is effective in terms of the number of tumors in which complete ablation is found on pathology result.

MICRA study: Minimally Invasive Complete Response Assessment of the breast after neoadjuvant systemic therapy

To assess whether core biopsies of the breast after neoadjuvant chemotherapy can reliably predict a pathologic complete response. We will therefore calculate the sensitivity, specificity, positive predictive value and negative predictive value of…

Primary Radioactive Iodine Seed localisation in the Axilla in axillary node positive breast cancer combined with Sentinel node procedure (RISAS) following neoadjuvant chemotherapy (NAC): a novel surgical approach to accurately assess axillary response to neoadjuvant systemic therapy, thereby reducing future need for completion axillary lymph node dissection and subsequent morbidity

The main goal of this study is to examine the accuracy (identification rate of the MARI-node and Sentinel node, sensitivity, negative predictive value (NPV) and false-negative rate (FNR)) of the RISAS procedure compared to the current standard…

Using optical spectroscopy for the detection of positive resection margins for invasive ductal carcinoma and ductal carcinoma in situ during breast conserving surgery

To assess the sensitivity and specificity of optical spectroscopy for the detection of Invasive Ductal Carcinoma (IDC) and Ductal Carcinoma In Situ (DCIS) deposits on resection margins during breast conserving surgery.

A radiopaque hydrogel to improve target definition of boost or partial breast irradiation in patients with low cavity visualization scores

Primary objective: Estimate the added value of using hydrogel in addition to clips only in terms of the Conformity Index (Cx) of tumorbed delineationSecondary objectives: Estimate the Cavity Visualisation Score (CVS), distance between the center of…