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Parent-child relationship, cognitive development and social-emotional functioning in children with intestinal failure;(PICASsO-study = Pediatric Intestinal failure: Cognitive And Social-emotional Outcomes)

(1) To assess parent-child attachment and interaction in a cohort of children and adolescents known with IF and (a history of) home PN dependence, and (2) to assess cognitive development and social-emotional functioning in these children.

The effect of a gastric bypass on the pharmacokinetics of citalopram

Primary objective: Determine whether a RYGB operation causes a clinically significant decrease in AUC (area under serum concentration-time curve) of citalopram three months after surgery in comparison with the situation before the operation.…

Assessing optimal treatment settings for the ablation of locally advanced pancreatic cancer with CT-guided percutaneous irreversible electroporation: a randomized feasibility study.

The objective of this study is to compare two IRE protocols for the treatment of LAPC that are currently being used in clinical treatment, to allow for the determination (based on survival and co-morbidity) of the optimal treatment protocol for IRE…

The OCEANS trial: fluorescence guided surgery with methylene blue for better visualization of small intestine neuroendocrine tumors: a feasibility study.

The aim of the study is to investigate whether SI-NET's can be visualized with Methylene Blue (MB) and near-infrared (NIR) fluorescence imaging.

Functional Ultrasound and the success of Sacral NeuroModulation in Fecal Incontinence

The aim of this study is to describe the difference in function of the anal sphincter, measured with functional ultrasound (4D transperineal ultrasound [TPUS] derived strain), before and after SNM as a treatment for fecal incontinence.Secondary…

Feasibility of Pre-emptive VACStent Placement after Ivor Lewis Esophagectomy, to Prevent Anastomotic Leakage (PREVENT feasibility study)

We aim to evaluate the technical and logistic feasibility and safety of pre-emptive VACStent placement in patients undergoing esophagectomy with gastric conduit reconstruction, to prevent anastomotic leakage by early endoscopic vacuum therapy (EVT…

Organ preservation in patients with a good clinical response after neoadjuvant (chemo)radiation for rectal cancer: optimization of treatment strategies and defining the role of additional contact x-ray brachytherapy versus extending the waiting interval and local excision.

The aim of this study is to investigate which rate of organ preservation can be achieved in patients with rectal cancer treated with neoadjuvant (chemo)radiotherapy with a good clinical response, and to optimize the different treatment strategies (…

Percutaneous intratumoural holmium microspheres brachytherapy for patients with pancreatic cancer;
a single centre, prospective safety and feasibility study

To test the feasibility and safety of minimally invasive CT-guided percutaneous holmium-166 microsphere brachytherapy in patients suffering from irresectable pancreatic cancer.

The perioperative microbiota composition in colorectal surgery patients receiving oral antibiotics or no oral antibiotics

Primary Objective: Exploring peri-operative changes in microbiota composition between patient receiving oral antibiotics, oral antibiotics with amphotericin B or no oral prophylaxis, performed by 16S rRNA sequencing, analyzed by Microbiome Center…

Randomized Controlled Trial of Laparoscopic Primary Diaphragm Repair with Sutures Alone versus Sutures Reinforced with Mesh for Hiatus Hernia: A Long-Term Follow-Up

To assess the recurrence of hiatal hernia five to ten years after repair using sutures versus sutures reinforced with non-absorbable mesh.

Cardiac and intramuscular adaptations following short-term exercise prehabilitation in unfit patients scheduled to undergo hepatic or pancreatic surgery

The main objective is to assess the central (cardiac function) and peripheral (skeletal muscle function) physiological adaptations in response to exercise prehabilitation.

*Improving clinical management of colon cancer through CONNECTION, a nation-wide Colon Cancer Registry and Stratification effort.*

Primary objective:Evaluation of the pathological tumour response to neoadjuvant systemic chemotherapy per CMS subtype in patients with microsatellite stable high risk stage II and stage III colon cancer.Secondary Objectives: • Evaluation of the…

Multicentre, randomised controlled trial comparing TRansanal minimal InvAsive Surgery (TAMIS) and endoscopic Submucosal dIsseCtion (ESD) for resection of non-pedunculated rectal lesions.

The aim of this study is to compare both procedures with regard to recurrence rates and complete (R0) resection rate, and to put this into perspective against the costs and complication rates of both strategies and the burden perceived by patients…

SGM-101 tumor-targeted fluorescence endoscopy to enable discrimination of malignant from benign tissue in rectal polyps with suspected T1 adenocarcinoma or high grade dysplasia: a feasibility study

This study has been transitioned to CTIS with ID 2024-510769-41-00 check the CTIS register for the current data. The main objective is to investigate the feasibility of a tumour-targeted fluorescent tracer SGM-101, combined with the use of the CE-…

Towards Response guided ADAptive Radiotherapy for organ preserving treatment of intermediate risk rectal cancer: a phase I dose finding trial

The main objective is to determine the maximum tolerated dose (MTD) that will be the recommended radiation dose for the phase 2 study, in which we intend on using a MR-guided boost after SCRT in patients with intermediate risk rectal cancer to…

Concomitant intraperitoneal and systemic chemotherapy in patients with extensive peritoneal carcinomatosis of gastric origin

This study has been transitioned to CTIS with ID 2024-516265-37-00 check the CTIS register for the current data. The primary goal of the study is to establish the maximum tolerated dose (MTD) of intraperitoneal administration of irinotecan, added to…

External beam radiation therapy versus stent insertion for dysphagia relief in esophageal cancer: a multi-center randomized trial

Primary objectiveThe primary objective of this study is to compare the efficacy of EBRT versus SEMS insertion for palliation of malignant dysphagia in esophageal cancer patients at 4 weeks after start of treatment.Secondary objectivesSecondary…

VITAMin Insufficiency in esophagogastric Neoplasms

To identify which micronutrient deficiencies are most common after surgery for esophagogastric neoplasms and to observe the effect of supplementation.

Predictive factors for anastomotic leakage after colorectal surgery (pREdictVE factors for AL --> REVEAL)

To investigate whether recently identified patient-specific factors can predict the occurrence of anastomotic leakage in patients undergoing elective surgery for colorectal cancer. Secondary: to develop a predictive model/diagnostic algorithm for…

Value of 3D Anal Manometry in anal Fistula Surgery: AMFI study

To investigate if the pre- and/or postoperative 3D-HRAM and 3 dimensional endo-anal ultrasound (3D-EAUS) might be a predictor for fecal incontinence after fistulotomy by evaluating changes in anorectal function and correlate this with the Fecal…