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Tumour educated platelets in the (early) diagnosis of ovarian cancer.

Primary objective:To distinguish benign ovarium lesions from early cancer lesions, based upon their platelet RNA profile. Secondary objectives:* Evaluate the diagnostic accuracy of platelet RNA profiling in detecting early-stage ovarium cancer…

Intra-operative near-infrared fluorescence imaging of the bowel during endometriosis surgery with indocyanine green: a pilot study

The primary objective is to assess the feasibility of intravenous injection of ICG to detect the border between healthy - and therefore fluorescent - bowel versus endometriosis.

A RCT of direct- versus indirect bilateral- sacrospinous ligament fixation for surgical correction of apical prolapse stage 2 or more.

1. To asses non-inferiority of BSC mesh in surgical success (= anatomic cure, subjective improvement and no re-treatment necessary) in the treatment of apical prolapse compared to unilateral SSLF at 12 months;2. Improvement of quality of life…

Advanced Pivotal Study for Safety & Efficacy of AltaSeal® a Hysteroscopically Placed Mechanical Occlusion Implant for Hysteroscopic Sterilisation

The primary objective of this clinical trial is to evaluate the safety and effectiveness of the AltaSeal® implants to provide bilateral mechanical occlusion of the fallopian tubes resulting prevention of pregnancy.

Intraoperative near-infrared fluorescence imaging of endometriosis with OTL38: a pilot study

Primary objective:- To assess the feasibility of a single intravenous injection of OTL38 in detecting endometriosis during surgery by determining the concordance between fluorescent signal and histopathological confirmed endometriotic tissue.- To…

Biomechanical Assessment of the Vaginal Wall for Pelvic Organ Prolapse

To assess 1) the feasibility of in vivo measurement of biomechanical properties of the vaginal wall with the use of cutometry (Cutometer MPA 580 4mm) and indentometry (Indentometer IDM 800) and 2) the biomechanical properties of the vaginal wall.

Pessary or surgery for symptomatic pelvic organ prolapse

The primary objective is to compare the effectiveness and cost-effectiveness of pessary versus surgery as initial treatment formoderate to severe symptomatic pelvic organ prolapse (POP) in women at two year after initiation of treatment.The…

The Use of Indocyanine Green-Based Fluorescence Imaging for Intraoperative Detection of Peritoneal Endometriosis

Objective: Using near-infrared fluorescence (NIRF) with a Karl Storz® NIR fluorescence laparoscope to provide a real-time intra-operative enhanced visualization of endometriosis during diagnostic laparoscopy. Thus improving identification of…

Evaluation of pelvic organ prolapse using upright magnetic resonance imaging

An explorative study, that will include 15 patients and 15 volunteers without pelvic floor disorders, will be conducted to evaluate the possibilities of an open 0.25T MRI- system to assess the pelvic floor and to get a better understanding of the…

Determine the feasibility of detecting endometriosis during surgery using a molecular targeted fluorescent imaging tracer

The main objective of this pilot study is to investigate the feasibility of fluorescence imaging with the fluorescence agent bevacizumab-800CW to detect endometriosis tissue.