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Ga-68-DOTA-(RGD)2 PET/CT: imaging angiogenesis in patients with low-flow vascular malformations

The primary objective of this study is to measure whether αvβ3 integrin expression and tracer uptake values of 68Ga-DOTA-(RGD)2 change in patients with (recurrent) low-flow vascular malformations after embolization therapy.

Resveratrol as potential aortic growth inhibitor in patients with Marfan Syndrome

The aim of the study is to obtain sufficient data on beneficial effects of Resveratrol on aortic aneurysm expansion rate and functional properties in patients with Marfan syndrome to justify a phase IIb or a phase III randomized trial.

Efficacy and safety of oral itraconazole in the reduction of epistaxis severity in hereditary hemorrhagic telangiectasia

5.1 Study hypothesisThe primary study hypothesis states that oral treatment with itraconazole will reduce the epistaxis severity score (ESS) due to the anti-angiogenic effects of itraconazole.5.2 Research question and primary outcomeWhat is the…