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An open-label, multiple-dose, sequential, 2 treatment period study to evaluate the effect of QBW251 on the pharmacokinetics and pharmacodynamics of a monophasic oral contraceptive in pre-menopausal healthy female volunteers

- To assess the effect of QBW251 on the pharmacokinetics of a monophasic combined oral contraceptive containing 30 µg ethinyl estradiol (EE) and 150 µg levonorgestrel (LVG).- To assess the effect of QBW251 on the pharmacodynamics of a monophasic…

Cross-sectional study on determinants of contact dermatitis on the hands of construction workers: etiologic studies and development of a diagnostic tool

Primary objective is to determine the actual occurrence of and risk factors for OCD on the hands of Dutch construction workers.With these new insights into the risk factors for OCD, we aim to develop 1) a new diagnostic tool to be used by…

Parental Attitude towards CL ± P during pregnancy;To evaluate and obtain insight into psychological, social and moral factors in order to improve counseling.

To evaluate and obtain insight into psychological, social and moral factors in thoughts and attitudes of pregnant women and their partners carrying a fetus with an isolated CL ± P in order to improve counseling.

Treacher Collins syndrome: Genectis and OSAS

Primary objectives:1. To analyze the exact pathogenic mutations in the TCOF1 gene in TCS 2. To determine the severity, prevalence, natural course within the cohort TCS patients and potential metabolic and physical effects of OSAS in TCSSecondary…

Characteristics of Patients with Dystrophic Epidermolysis Bullosa

UMC Groningen part of research: to recruit patients with Dystrophic Epidermolysis Bullosa, in order to harvest keratinocytes for defining several characteristics of the EB population: antibodies to type VII collagen, presence of type VII NC1 domain…

Molecular pathology of skin disease

To elucidate the molecular basis of skin disease.

Field testing of a Patient-Reported Outcome Measure for Cleft Lip and Palate:
The CLEFT-Q

To contribute to completion of the psychometric development of the Cleft Q

Capillary malformations, from genotype to phenotype: a focus on endothelial function

We aim to provide preliminary information on the presence of GNAQ, GNA11, RASA1 or PIK3CA gene mutations, assess the endothelial cell properties and compare it to the phenotypic characteristics of the PWSs of affected patients. This will lead to a…

Treatment of Skin Severity in Ichthyosis with Hyperbaric Oxygen Therapy

To assess clinical improvement of skin severity in patients with ichthyosis

The wound care of children with Epidermolysis Bullosa as a source of stress for their parents and themselves.

The overall objective of this study is gaining insight into needs and options for psychological treatment of parents and their children with EB with regard to problems related to wound care.Specific objectives are: 1. To examine coping strategies of…

A Multi-center Study to Evaluate the Pharmacokinetics of Diacerein and Rhein and the Safety of Diacerein after Maximum Use, Topical Administration of CCP-020 (Diacerein 1% ointment) to Patients with Epidermolysis Bullosa (EB)

The primary objective of the study is to descriptively characterize the single-dose and steadystatePharmacokinetics (PK) of diacerein (if quantifiable) and its active metabolite, rhein, after topical application of CCP-020 (diacerein 1% ointment)…