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Small bowel surveillance in patients with Peutz-Jeghers syndrome: comparing MR enteroclysis with double balloon enteroscopy.

The aim of this prospective study is 1) to evaluate the diagnostic efficacy of DBE in comparison to MRE as surveillance technique of the small-bowel in PJS patients, 2) to analyze patient burden and quality of life with DBE and MRE, and 3) to…

Evidence based therapy of pulmonary hypertension in congenital diaphragmatic hernia - A prospective observational study

The primary objective is to determine if echocardiography in combination with plasma biomarkers can be used as a potential predictor for pulmonary hypertension. The secondary objectives are assessment of a potential correlation between…

Endoscopic surveillance using narrow-band imaging in patients with hyperplastic polyposis syndrome (HPS): A multicentre cohort study

To prospectively compare NBI with HRE for the detection and differentiation of polyps in HPS in a large multicentre HPS cohort (n~125).

Combined pan-chromoendoscopy and confocal endomicroscopy for the diagnosis of colorectal neoplasia in subjects at high-risk for colorectal cancer

Objective: Two issues will be addressed:i) does pan-colonic chromoendoscopy improve the diagnostic yield of colonic polyps (and in particular flat lesions) as compared to conventional colonoscopy?ii) does pan-colonic chomoendoscopy combined with…

Colonoscopic surveillance using narrow-band imaging in patients with hyperplastic polyposis syndrome (HPS)

The aims of this study are to assess the additional value of NBI in comparison to white-light endoscopy (WLE) for the detection and classification of HPs, SAs, MPs and adenomas in patients with HPS.

Tracheomalacia in babies after correction of Esophageal Atresia - A First step to reduce respiratory morbidity

The main objective is to research the practicability of postoperative fLTB through the endotracheal tube, right before/during planned extubation in the intensive care unit (ICU) in newborn babies after EA correction.

The effect of changing CO2 levels on perioperative cerebral and microcirculatory hemodynamics in infants undergoing laparoscopic surgery

Primarily, to assess the effect of changing CO2 levels on the sublingual microcirculation, cerebral oxygenation, and cerebral perfusion. Secondarily, to assess if and how sublingual microcirculatory parameters, parameters of cerebral oxygenation,…