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Botulinum toxin for treating calf muscle spasticity in Hereditary Spastic Paraparesis (HSP): functional effects on dynamic balance and gait

To show that an individually tailored treatment of the calf muscles with BTX-A promotes the balance capacity and mobility of HSP patients by an effective reduction of spasticity while preserving muscle strength. This explorative study uses a pre-…

EURAP and Development. A study on behavioral-, cognitive- and motordevelopment of children exposed to valproic acid in utero - a Dutch pilot study in anticipation of the international EURAP/NCEP study (European Register of Antiepileptic Drugs and Pregnancy / Neurocognitive Extension Protocol)

The objective of the study is two-fold:First, we want to improve the design of the study for future extension, by critical evaluation of the efficacy, the instruments used and the outcome measures. Second, we want to assess the cognitive and…

Long-term effects of lithium on the motoric and/or psychological development of children who are exposed to lithium during pregnancy.

The objective of the study is to investigate the long-termeffects of lithium on the development of children who are exposed to lithium during pregnancy.