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Gene expression during ciliagenesis: Towards a novel candidate gene list for Primary Ciliary Dyskinesia

We aim to assess gene expression patterns in cilia-producing cells from healthy controls to develop a candidate gene list for PCD.

Rhinosinusitis and nasal polyps in adults with Cystic Fibrosis

Investigate the prevalence of rhinosinusitis and/or nasal polyps in adult patients with Cystic Fibrosis. Also several aspects of sinonasal disease are investigated; quality of life, correlation between phenotype and genotype, microbiology, anatomy…

Genetic sequencing study in Primary Ciliary Dyskinesia.

Objectives: The aim of this study is to:I Identify pathogenic mutations in novel genes, causing PCDII Develop a diagnostic PCD test, based on MPSIII Validate MPS technique for PCD.

Does a different number, phenotype and/or function of regulatory T cells contribute to the development of asthma?

To assess whether TW and PW show differences in number, phenotype or function of regulatory T-cells in peripheral blood samples. Details on study determinants will be based on the outcome of the pilotstudy (Regulatory T cells in asthma; PREDART0807…

Continuous Glucose Monitoring System in patients with Cystic Fibrosis

Investigate the CGMS results in comparison with an OGTT and one-day self monitoring of blood glucose. Thereby compare the glucose patterns of patients with an impaired glucose tolerance to patient with a normal glucose tolerance and CFRD.

MONITOR CF: Monocytes In TiMaSCAN for monitoring respiratory infections in Cystic Fibrosis

Our main aim is to validate the TiMaSCAN as both a diagnostic and monitoring tool in the treatment of pulmonary exacerbations in CF patients.

I-BALL 2: Non-invasive Disease Monitoring in Infants with Cystic Fibrosis

To validate our previous findings, and to continue and deepen our exploration of biomarkers in BALF, providing endpoints that correlate with disease progression. We will do this through in-depth cellular and molecular profiling of BALF and blood,…