51 results
Primary objective1) To study the frequency of mutations in this gene in patients with central hypothyroidism and their first- and second-degree relativesSecondary objective: 2) To determine the clinical, biochemical and radiological consequences of…
To describe the treatment expectations of patients with a pituitary tumor undergoing treatment as well as patients' evaluation of the perioperative trajectory. Moreover, we will determine the fulfilment of expectations and clinical outcomes…
The purpose of this study is to look at the effect of changing from monthly (4 weekly) injections of your usual treatment (octreotide LAR) to less frequent treatment (once every 6 or 8 weeks) with lanreotide Autogel 120 mg injections. The study…
To find new genes causing congenital MPHD associated with the characteristic MRI abnormalities of ectopic posterior pituitary gland and absent/thin pituitary stalk.
Primary objective: Safety.Secondary objective: Efficacy.
The primary objective of this study is to assess the relation between the short term metabolic changes after start of rhGH therapy and the long term change in height SDS after one and two years of treatment. Secondly, we want to assess the effects…
Next to cardiovascular risk factors (main objectives: body composition and lipid profile; secondary objectives: remainder) we investigate the effect of GH treatment on glucose metabolism, physical performance, and neuropsychological functioning of…
Determination of prognostic value of intraoperative growth hormone levels on postoperative curation for acromegaly in patients undergoing transsphenoidal resection of pituitary adenoma.
To assess Bone Material Strength (BMS) in patients with acromegaly with fractures and without fractures.
The primary endopoint is to determine whether ketoconazole/octreotide combination therapy, followed by octreotide monotherapy, is an effective treatment for Cushing's disease. Secundary endpoints address the effects of this therapy on bone…
Primary objective: Assessment of the value of the short-term (2 weeks) response of IGF-I (peak IGF-I SDS) to GH in a dosage of 1.4 mg/m2/day (as part of a dose-escalation IGF-I generation test) in comparison to baseline IGF-I to predict the 1 year…
The primary objective of this study is to assess the relation between the short term metabolic changes after start of rhGH therapy and the long term change in height SDS after one year of treatment. Secondly, we want to assess the effects of GH on…
To study the effects of transient severe endogenous stress hormone exposure on the structure and functioning of brains circuitry regulating emotion, and the association with cognition and psychopathological symptoms.
To evaluate the efficacy of Lanreotide Autogel 120 mg when used as primary medical treatment in untreated de novo acromegalic patients with macroadenoma
To investigate if there is a correlation between the peak GH concentrations after ingestion of gelatin protein and the peak GH concentrations after the two standard tests (GHST) in order to discriminate between GHD and non-GHD. To investigate the…
To investigate the differences in facial analysis, between patients with acromegaly, being in remission, and healthy subjects, and to investigate the changes in relational proportions between these facial structures.
The main objective of the study is to evaluate differences in body size, body composition and metabolic health at 7 years between children fed postdischarge formula and term formula. Secondary objectives are differences in bone mineralization and…
The aim of this study is to investigate whether a physiologically low hydrocortisone (HC) dose is better for cognition as compared to a high hydrocortisone dose. In addition, quality of life, metabolic profile and somatosensation will be described…
1) Follow-up study of project 2011_371:To determine whether the 27 children found in this study actually had a central hypothyroidism, by complementing the existing data with details from the medical records. The data used in the first study were…
The primary objective is to study the effects of GH substitution therapy in adult GH deficient survivors of childhood cancer. Primary endpoints are organ size, renal function and capillary density of the skin.