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Unraveling genetic causes of congenital multiple pituitary hormone deficiencies

To find new genes causing congenital MPHD associated with the characteristic MRI abnormalities of ectopic posterior pituitary gland and absent/thin pituitary stalk.

Facial analysis in acromegaly: a cross sectional study of persistent craniofacial changes after remission.

To investigate the differences in facial analysis, between patients with acromegaly, being in remission, and healthy subjects, and to investigate the changes in relational proportions between these facial structures.

Postdischarge nutrition in infants born <32 weeks gestation and/or <1500 grams birth weight: relation with growth, body composition and metabolic health at 7 years (STEP 2)

The main objective of the study is to evaluate differences in body size, body composition and metabolic health at 7 years between children fed postdischarge formula and term formula. Secondary objectives are differences in bone mineralization and…

Effects of growth hormone (GH) replacement therapy in GH deficient adult childhood cancer survivors on organ size and microvascularisation of kidney and skin.

The primary objective is to study the effects of GH substitution therapy in adult GH deficient survivors of childhood cancer. Primary endpoints are organ size, renal function and capillary density of the skin.

Hypopituitarism after Severe Traumatic Brain Injury, an observational study

To study the prevalence of hypopituitarism and osteoporosis in patients 5 tot 10 years after severe traumatic brain injury

Day-night rhythmicity in patients with a nonfunctioning pituitary macroadenoma; a prospective study

Research question:1. Do patients exhibit disturbances of sleep duration or circadian locomotor rhythmicity before surgery? 2. Do these variables change after surgery?

Arthropathy in acromegaly: Evaluation of Progression, characteristics of Osteophytes, quality of Life and medical care, Imaging and Structure of cartilage in acromegalic patients 2016 (ACROPOLIS 2016)

We aim to further study the characteristics of joint disease in acromegaly and its progression, in order to improve care for this patient group and to get insight into the pathogenesis of osteophytes and cartilage hypertrophy in acromegaly and in…

Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 onderzoek:
Growth hormone deficiency in children, after treatment for childhood cancer

• To assess the prevalence of short stature, in combination with an aberrant IGF-1 in combination with IGF-BP3 in the entire cohort of childhood cancer survivors and the therapy related risk factors.• To assess the distribution of IGF-1 and IGF-BP3…

Hypothalamic damage in pediatric brain tumor survivors: Effects of Radiotherapy and associations with Cognitive functioning

Primary objective: Development of a normal tissue complication probability (NTCP) model for hypothalamic dysfunction (for severe hypothalamic dysfunction, named hypothalamic syndrome) in childhood brain tumor survivors, incorporating cranial…

Functional magnetic resonance imaging of human hypothalamic responses to oral glucose ingestion in subjects with obesity before and after lifestyle intervention.

The objective of the study is to determine hypothalamic function in response to oral glucose ingestion in subjects with obesity before and after the start of a combined lifestyle intervention (CLI).

Congenital central hypothyroidism plusminus ACTH or growth hormone deficiency: etiology and outcome

In this predominantly observational study all patients diagnosed with CH-C in the Netherlands between 1-1-1995 and 1-1-2015 will be traced and the following research questions will be addressed:1) What is the mortality rate associated with early…