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An open-label, single-dose study to evaluate the excretion and metabolism of oral [14C]­-ONO-5788, and absolute bioavailability of oral ONO-5788 in healthy adult male subjects

The purpose of this study is to investigate how quickly and to what extent ONO-5788 is absorbed and how ONO5788 is eliminated from the body. . ONO-5788 will be labelled with 14-Carbon (14C) and is thus radioactive. In this way ONO-5788 can be traced…

An open-label, multi-center, roll-over study to assess long term safety in patients with endogenous Cushing*s syndrome who have completed a prior Novartis-sponsored osilodrostat (LCI699) study and are judged by the investigator to benefit from continued treatment with osilodrostat

To evaluatie the long term safety of treatment with osilodrostat for patients with Cushing Syndrome. In addition to evaluating the proportion of patients with clinical benefit (as assessed by the investigator) and determening frequency, severity and…

Identification of the posterior lobe of the human pituitary gland during surgery using its electrophysiological, neural signature

To record and analyse the electrophysiological properties and differences of the human pituitary gland, i.e. the anterior lobe, posterior lobe and adenoma.

Hypothalamic damage in pediatric brain tumor survivors: Effects of Radiotherapy and associations with Cognitive functioning

Primary objective: Development of a normal tissue complication probability (NTCP) model for hypothalamic dysfunction (for severe hypothalamic dysfunction, named hypothalamic syndrome) in childhood brain tumor survivors, incorporating cranial…

Functional magnetic resonance imaging of human hypothalamic responses to oral glucose ingestion in subjects with obesity before and after lifestyle intervention.

The objective of the study is to determine hypothalamic function in response to oral glucose ingestion in subjects with obesity before and after the start of a combined lifestyle intervention (CLI).

Short-term effects of a eucaloric ketogenic diet in acromegaly patients

To assess the efficacy of two weeks eucaloric ketogenic diet on GH and IGF-I levels in acromegaly patients.

Congenital central hypothyroidism plusminus ACTH or growth hormone deficiency: etiology and outcome

In this predominantly observational study all patients diagnosed with CH-C in the Netherlands between 1-1-1995 and 1-1-2015 will be traced and the following research questions will be addressed:1) What is the mortality rate associated with early…

Phase IIa, open label, dose ascending study to determine the maximum tolerated dose, safety and tolerability, pharmacokinetics and pharmacodynamics of a single dose of lanreotide PRF in subjects with acromegaly previously treated and controlled with either ocreotide LAR or lanreotide Autogel.

Primary:*To identify the maximum tolerated dose (MTD) and to investigate the pharmacokinetics (PK) of a single dose of lanreotide PRF in subjects with acromegalySecondary:*To investigate the safety and tolerability of a single dose of lanreotide PRF…

A new dietary intervention for children with hypothalamic obesity after treatment for a craniopharyngioma: a pilot-study

This pilot-study is designed to assess the feasibility and efficacy of a new dietary intervention (Happy Weight Dotsplan) and therefore to learn if it might be effective on a broad scale with the inclusion of a larger cohort nationwide. We will…

Neonatal reference values for thyroid hormones and validation of dried blood spot measurements in the neonatal period

1. To establish reference intervals for thyroid hormones in plasma at the time of the neonatal screening (day 3-7 of life).2. To establish reference intervals for thyroid hormones in plasma around the 14th day of life.3. To compare the…

The EndoWatch: a smart wearable that serves as *external hypothalamus*

The aim of this study is to determine whether this smart wristband can actually support patients and their parents in managing the consequences of hypothalamic dysfunction. We will investigate what kind of support patients, parents, or caregivers…