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Mutations in thyroid hormone receptor alpha 2

The family with the TRα2 premature stop enables us to investigate the biological role of the orphan wild-type TRα2 and the consequences of its dysfunction. The primary objectives of this proposal are (i) to search for a biological function of TRα2…

Cognitive and motor development, nerve function, somatic growth and (pubertal) development, and (spontaneous) thyroid function in 10,5 years old Down syndrome children after thyroxine or placebo treatment until the age of 2 years.

To find out whether T4 treatment of Down syndrome newborns until the age of 2 years compared with placebo treatment results in better cognitive or motor development at the age of 10 years and 6-8 months, and whether it is safe with regard to nerve…